Rifampicin/isoniazid/pyrazinamide

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Rifampicin/isoniazid/pyrazinamide
Combination of
Rifampicin Rifamycin antibiotic
Isoniazid Anti-tuberculosis medication
Pyrazinamide Anti-tuberculosis medication
Clinical data
Trade names Rifater, Trifazid, others
AHFS/Drugs.com FDA Professional Drug Information
License data
Routes of
administration
By mouth
ATC code
Legal status
Legal status
  • US: ℞-only
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
  • none
KEGG
   (verify)
3D structure Rifampicin/isoniazid/pyrazinamide Rifampicin 3D 1i6v.png
3D structure Rifampicin/isoniazid/pyrazinamide

Rifampicin/isoniazid/pyrazinamide, also known as rifampin/isoniazid/pyrazinamide, and sold under the trade name Rifater, is a medication used to treat tuberculosis. [1] It is a fixed dose combination of rifampicin, isoniazid, and pyrazinamide. [1] It is used either by itself or along with other antituberculosis medication. [1] It is taken by mouth. [1]

Contents

Side effects are those of the underlying medications. [1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness. [2] Severe side effects include liver problems. [3] Use in those under the age of 15 may not be appropriate. [3] It is unclear if use in pregnancy is safe for the baby. [3]

Rifampicin/isoniazid/pyrazinamide was approved for medical use in the United States in 1994. [3] It is on the World Health Organization's List of Essential Medicines. [4]

Medical uses

The hope of a fixed-dose combination pill is to increase the likelihood that people will take all of three medications. [5] Also, if people forget to take one or two of their drugs, they might not then develop resistance to the remaining drugs.[ citation needed ]

Society and culture

It is manufactured by Aventis.[ citation needed ]

See also

Related Research Articles

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Isoniazid, also known as isonicotinic acid hydrazide (INH), is an antibiotic used for the treatment of tuberculosis. For active tuberculosis, it is often used together with rifampicin, pyrazinamide, and either streptomycin or ethambutol. For latent tuberculosis, it is often used alone. It may also be used for atypical types of mycobacteria, such as M. avium, M. kansasii, and M. xenopi. It is usually taken by mouth, but may be used by injection into muscle.

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Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease. It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended" for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended. Rifampicin may be given either by mouth or intravenously.

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References

  1. 1 2 3 4 5 World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 143. hdl: 10665/44053 . ISBN   9789241547659.
  2. "Rifater Side Effects in Detail - Drugs.com". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 18 December 2016.
  3. 1 2 3 4 "Rifater - FDA prescribing information, side effects and uses". www.drugs.com. October 2016. Archived from the original on 21 December 2016. Retrieved 18 December 2016.
  4. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl: 10665/325771 . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  5. Brown MJ, Sharma P, Bennett PN (30 July 2012). Clinical Pharmacology. Elsevier Health Sciences. p. 204. ISBN   978-0-7020-5113-5.