Creolin

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Creolin is a generic name for disinfectants whose composition varies according to origin. One of its uses is as a disinfectant. It is extracted from the dry distillation of wood. The residue remaining in the autoclave vessel is a dark, syrupy mass called creosote, which is composed mainly of phenolic acid and cresylic acid. The original composition of creolin was this creosote tar oil, caustic soda, soaps, and very little water. It is of low technology and a very powerful disinfectant. [1]

Contents

History

The article on Newland, Kingston upon Hull, mentions that Pearsons was established by William Edward Pearson in 1880. In Italy the company that owns the brand Creolin, Guglielmo Pearson S.r.l. of Genoa Italy, is the only manufacturer of the disinfectant. Internationally, creolin also corresponds to the trade name of other disinfectant products for example by Mark Cansick Co, in addition to the same William Pearson (chemicals).[ citation needed ]

From 1888 to date the creolin has undergone several changes. The original composition was creosote, caustic soda, soaps, and very little water. Its use was multiple: in the field of medicine (specifically as a hospital grade disinfectant) in the animal husbandry and veterinary sector. In the field of motor restoration works, creolin (and the vapors of the same) is used to return to the original condition of the casting of oil-stained aluminum parts.[ citation needed ]

By 1888, creolin 1 percent strength was used for the wound dressing of burns. [2]

In 1889, Professor Georges Dujardin-Beaumetz of Paris France published in The Therapeutic Gazette an essay entitled "Prophylactic Hygiene Lecture V.- On Disinfectants":

While extolling the virtues of some new remedies, it will not be amiss to call attention to the drawbacks and disadvantages of another new drug, which of late has become quite popular, viz., creolin. Although the disinfectant properties of creolin have now been definitely proved, the drug has certain disadvantages which contraindicate its use for certain purposes. The solution of creolin is wholly opaque, hence it cannot well be used for the [instrument] basin, in which the instruments are placed before an operation, as it renders their finding difficult. Another disadvantage is that it renders everything with which it comes in contact so soapy that it materially interferes with the firm hold on instruments and parts to be operated upon. That creolin is by no means a harmless agent, but can give rise to serious intoxication, has been amply proved by the publications of Rosin and Cramer. [3]

In 1897, an import agent in Rio de Janeiro was advertising "Creolin-Pearson" as "The best desinfectant for vessels. Recommended for daily use especially during epidemics." [4]

Such was its power as a hospital disinfectant that by 1901, American nurses were urged it use in Methods of Disinfection Recommended by the Department of Health of the City of New York . [5]

In 1915, Parcher's Drug Store was advertising creolin alongside such staples as Pyrox, Lime and Sulphur, Hellebore, Paris Green, Kerso, Blue Vitriol, Arsenate of Lead, Carbonal, Pine Tar, Sheep Dip, Chloride Lime, Rosin, Bi-Sulphide Carbon, Copperas, Washing Fluid, Sulpho Napthol, Sprayers, Cow Ease, Roach Powder, Moth Balls, and Nyals Family Remedies. [6]

In the early 1930s creolin production from peat tar began in Gus-Khrustalny, Vladimir Oblast. From 1942, "due to urgent necessity of disinfectants for the needs of the Eastern Front of WW2", creolin production was expanded to hundreds of tons per annum. [7]

The Plough company acquired the US Creolin Company from Merck & Co. in September 1958. [8]

In 2015, Iranian academics at Mazandaran University performed a Nosocomial infections study on the "Efficiency of some disinfectants (Cidex, Deconex, and Creolin) against E.coli". [9]

Composition

Creolin is a natural disinfectant that is extracted from the dry distillation of wood. This procedure consists of distilling the wood in large autoclaves. From the vapors that emanate from this distillation extracts the vegetable aguarrás also known as essence of turpentine. The residue remaining in the autoclave vessel is a dark, syrupy mass called creosote. It is composed mainly of phenol (phenolic acid) and cresol (cresylic acid). It is a very powerful disinfectant, of natural origin, and is used to make different compounds intended for cleaning and disinfection. [1]

The main active ingredient are phenols (26%), coal tar neutral oils (51%), soaps (13%) and water (10%) . The main toxicity of this product is that of phenols, which are non-specific cellular toxins causing damage to the gastrointestinal, hepatic, renal and neurological systems. [10]

Cresylic Acid is a composition of a number of mixtures of several acids that are derived from petroleum and coal tar, boiled above 204 °C, contain varying amounts of cresols and other phenols, and are used in resins, disinfectants, solvents, preservatives, wood preservatives and electrical insulation.[ citation needed ]

o-Cresol is used as a solvent, disinfectant, and chemical intermediate.[ citation needed ]

m-Cresol is used to produce certain herbicides, as a precursor to the pyrethroid insecticides, to produce antioxidants, and to manufacture the explosive, 2,4,6-nitro-m-cresol.[ citation needed ]

p-Cresol is used largely in the formulation of antioxidants and in the fragrance and dye industries.

The EPA has classified o-cresol, m-cresol, and p-cresol as Group C: possible human carcinogens. [11]

Exposure

Exposure to 26% Creolin disinfectant (26% phenol) produces vomiting, coughing, stridor, tissue sloughing and first degree burns in patients with oral exposure and with dermal exposure. Central nervous system toxicity from exposure to a high concentration phenol containing cleaning product appears to be rapid in onset. [12]

Mechanism of action

For cresol bactericides or disinfectants the mechanism of action is due to the destruction of bacterial cell membranes. [13] [14]

Uses

The ideal concentration for the manufacture of disinfectants is a phenol content of 15% on the product. In this way, when the disinfectant is prepared for use, it will always have a final concentration of phenols higher than 1%, which is used for cleaning and disinfection.[ citation needed ]

For the preparation of phenol disinfectants, liquid soaps of different types are used which aid in cleaning and, mainly, the solubility of the active substance (phenols or cresols). It has been standard practice to use soaps which, upon dissolving the finished product in water, give a white, milk-like emulsion. This emulsion contains, dissolved in small particles, the active material, whether phenols or cresols.[ citation needed ]

Bactericidal agent

Austin Flint II remarked in 1888 that for cases in which Bacillus pyocyanus (Synonym Pseudomonas aeruginosa ) was found in patients' wound dressings, and cultivations of it obtained, if gauze impregnated with a creolin lotion containing less than 2 percent could be used for moistening the dressings and the dressings were no longer found to contain the pathogen. Concentrations of creolin higher than 2 percent produced unbearable pain. [2]

Creolin has been shown to be effective in inactivating African swine fever virus. [15] [16]

Larvicidal agent: Oral myiasis

Treatment of Oral myiasis caused by screwworm larvae consisted of subcutaneous ivermectin therapy and the application of a phenol preparation (10% creolin) as a local measure for the control of larvae. Healing was uneventful in the six cases presented, and no undesirable reactions were observed throughout the period of treatment. [17]

Creolin Soap

Creolin Soap is not to be confused with Creolin the raw disinfectant which may contain a concentration of "20-26%" toxic phenols. [18] See Exposure.

The active ingredient in Creolin soap is cresylic acid. Creolin Soap is "advertised" as an anti-dandruff, lice treatment, hair root strengthener, hair loss treatment, scalp acne treatment and antibacterial. Unlike the undiluted disinfectant, Creolin soap is formulated for human use.

Hair

Creolin is also used as a home remedy for lice treatment. Recipes using drops of the concentrated disinfect with "20-26%" toxic phenols mixed with shampoo or mixed with the lather of bar soap can be found online.

There is no scientific evidence that Creolin promotes hair growth. [19] [20]

Voodoo

Creolin is commonly used as tar water in spiritual cleansing rituals performed by Voodoo, Hoodoo, Santeria and some Afro-American religion practitioners. [21]

Inappropriate uses

These vary greatly by jurisdiction. The 21st century American study of Vearrier et al. listed a number of undesirable uses of creolin, such as: bathing pets, deodorant, or for delousing hair. These can cause harm due to the toxicity of phenol. [18]

Related Research Articles

Coal tar is a thick dark liquid which is a by-product of the production of coke and coal gas from coal. It is a type of creosote. It has both medical and industrial uses. Medicinally it is a topical medication applied to skin to treat psoriasis and seborrheic dermatitis (dandruff). It may be used in combination with ultraviolet light therapy. Industrially it is a railroad tie preservative and used in the surfacing of roads. Coal tar was listed as a known human carcinogen in the first Report on Carcinogens from the U.S. Federal Government, issued in 1980.

<span class="mw-page-title-main">Phenol</span> Organic compound (C6H5OH)

Phenol is an aromatic organic compound with the molecular formula C6H5OH. It is a white crystalline solid that is volatile. The molecule consists of a phenyl group bonded to a hydroxy group. Mildly acidic, it requires careful handling because it can cause chemical burns.

<span class="mw-page-title-main">Creosote</span> Tar distillation byproduct used as wood preservative

Creosote is a category of carbonaceous chemicals formed by the distillation of various tars and pyrolysis of plant-derived material, such as wood, or fossil fuel. They are typically used as preservatives or antiseptics.

<span class="mw-page-title-main">Butylated hydroxytoluene</span> Chemical compound

Butylated hydroxytoluene (BHT), also known as dibutylhydroxytoluene, is a lipophilic organic compound, chemically a derivative of phenol, that is useful for its antioxidant properties. BHT is widely used to prevent free radical-mediated oxidation in fluids and other materials, and the regulations overseen by the U.S. F.D.A.—which considers BHT to be "generally recognized as safe"—allow small amounts to be added to foods. Despite this, and the earlier determination by the National Cancer Institute that BHT was noncarcinogenic in an animal model, societal concerns over its broad use have been expressed. BHT has also been postulated as an antiviral drug, but as of December 2022, use of BHT as a drug is not supported by the scientific literature and it has not been approved by any drug regulatory agency for use as an antiviral.

<span class="mw-page-title-main">Sodium hypochlorite</span> Chemical compound (known in solution as bleach)

Sodium hypochlorite is an alkaline inorganic chemical compound with the formula NaOCl. It is commonly known in a dilute aqueous solution as bleach or chlorine bleach. It is the sodium salt of hypochlorous acid, consisting of sodium cations and hypochlorite anions.

<span class="mw-page-title-main">Water purification</span> Process of removing impurities from water

Water purification is the process of removing undesirable chemicals, biological contaminants, suspended solids, and gases from water. The goal is to produce water that is fit for specific purposes. Most water is purified and disinfected for human consumption, but water purification may also be carried out for a variety of other purposes, including medical, pharmacological, chemical, and industrial applications. The history of water purification includes a wide variety of methods. The methods used include physical processes such as filtration, sedimentation, and distillation; biological processes such as slow sand filters or biologically active carbon; chemical processes such as flocculation and chlorination; and the use of electromagnetic radiation such as ultraviolet light.

Cresols are a group of aromatic organic compounds. They are widely-occurring phenols which may be either natural or manufactured. They are also categorized as methyl phenols. Cresols commonly occur as either solids or liquids because their melting points are generally close to room temperature. Like other types of phenols, they are slowly oxidized by exposure to air, and the resulting impurities often give the samples a yellow to brownish red tint. Cresols have an odor characteristic to that of other simple phenols, reminiscent to some of a "coal tar" smell. The name "cresol" is an adduct of phenol and their traditional source, creosote.

<span class="mw-page-title-main">Sterilization (microbiology)</span> Process that eliminates all biological agents on an object or in a volume

Sterilization refers to any process that removes, kills, or deactivates all forms of life and other biological agents present in or on a specific surface, object, or fluid. Sterilization can be achieved through various means, including heat, chemicals, irradiation, high pressure, and filtration. Sterilization is distinct from disinfection, sanitization, and pasteurization, in that those methods reduce rather than eliminate all forms of life and biological agents present. After sterilization, an object is referred to as being sterile or aseptic.

<span class="mw-page-title-main">Chlorine dioxide</span> Chemical compound

Chlorine dioxide is a chemical compound with the formula ClO2 that exists as yellowish-green gas above 11 °C, a reddish-brown liquid between 11 °C and −59 °C, and as bright orange crystals below −59 °C. It is usually handled as an aqueous solution. It is commonly used as a bleach. More recent developments have extended its applications in food processing and as a disinfectant.

<span class="mw-page-title-main">Disinfectant</span> Antimicrobial agent that inactivates or destroys microbes

A disinfectant is a chemical substance or compound used to inactivate or destroy microorganisms on inert surfaces. Disinfection does not necessarily kill all microorganisms, especially resistant bacterial spores; it is less effective than sterilization, which is an extreme physical or chemical process that kills all types of life. Disinfectants are generally distinguished from other antimicrobial agents such as antibiotics, which destroy microorganisms within the body, and antiseptics, which destroy microorganisms on living tissue. Disinfectants are also different from biocides—the latter are intended to destroy all forms of life, not just microorganisms. Disinfectants work by destroying the cell wall of microbes or interfering with their metabolism. It is also a form of decontamination, and can be defined as the process whereby physical or chemical methods are used to reduce the amount of pathogenic microorganisms on a surface.

<span class="mw-page-title-main">Benzalkonium chloride</span> Surfactant and antiseptic agent

Benzalkonium chloride, also known as alkyldimethylbenzylammonium chloride (ADBAC) and by the trade name Zephiran, is a type of cationic surfactant. It is an organic salt classified as a quaternary ammonium compound. ADBACs have three main categories of use: as a biocide, a cationic surfactant, and a phase transfer agent. ADBACs are a mixture of alkylbenzyldimethylammonium chlorides, in which the alkyl group has various even-numbered alkyl chain lengths.

An antimicrobial is an agent that kills microorganisms (microbicide) or stops their growth. Antimicrobial medicines can be grouped according to the microorganisms they act primarily against. For example, antibiotics are used against bacteria, and antifungals are used against fungi. They can also be classified according to their function. The use of antimicrobial medicines to treat infection is known as antimicrobial chemotherapy, while the use of antimicrobial medicines to prevent infection is known as antimicrobial prophylaxis.

<span class="mw-page-title-main">Pine tar</span> Chemical compound

Pine tar is a form of wood tar produced by the high temperature carbonization of pine wood in anoxic conditions. The wood is rapidly decomposed by applying heat and pressure in a closed container; the primary resulting products are charcoal and pine tar.

<span class="mw-page-title-main">Tar</span> Dark viscous organic liquid

Tar is a dark brown or black viscous liquid of hydrocarbons and free carbon, obtained from a wide variety of organic materials through destructive distillation. Tar can be produced from coal, wood, petroleum, or peat.

Chloroxylenol, also known as para-chloro-meta-xylenol (PCMX), is a chlorine substituted phenol with a white to off-white appearance and a phenolic odor. The discovery of chloroxylenol was the result of efforts to produce improved antiseptics that began at the end of the 1800s. First synthesized in Germany in 1923, it was borne out of the study of coal tar components that began a decade earlier.

Dakin's solution is a dilute solution of sodium hypochlorite and other stabilizing ingredients, traditionally used as an antiseptic, e.g. to cleanse wounds in order to prevent infection. The preparation was for a time called also Carrel–Dakin solution or Carrel–Dakin fluid.

<span class="mw-page-title-main">Lysol</span> Cleaning products brand name

Lysol is a brand of American cleaning and disinfecting products distributed by Reckitt, which markets the similar Dettol or Sagrotan in other markets. The line includes liquid solutions for hard and soft surfaces, air treatment, and hand washing. The active ingredient in many Lysol products is benzalkonium chloride, but the active ingredient in the Lysol "Power and Free" line is hydrogen peroxide. Lysol has been used since its invention in the late 19th century as a household and industrial cleaning agent, and previously as a medical disinfectant.

<span class="mw-page-title-main">Bleach</span> Chemicals used to whiten or disinfect

Bleach is the generic name for any chemical product that is used industrially or domestically to remove colour (whitening) from fabric or fiber or to disinfect after cleaning. It often refers specifically to a dilute solution of sodium hypochlorite, also called "liquid bleach".

<span class="mw-page-title-main">Dinoseb</span> Chemical compound used as a herbicide

Dinoseb is a common industry name for 6-sec-butyl-2,4-dinitrophenol, a herbicide in the dinitrophenol family. It is a crystalline orange solid which does not readily dissolve in water. Dinoseb is banned as an herbicide in the European Union (EU) and the United States because of its toxicity.

p-Chlorocresol, or 4-chloro-3-methylphenol (ClC6H3CH3OH), also known as p-chloro-m-cresol, is a potent disinfectant and antiseptic. It appears as a pinkish white crystalline solid. It is also used as a preservative in cosmetics and medicinal products for both humans and animals. It is used as an active ingredient in some preparations of veterinary medicines for tropical, oral and parenteral use. Normally, the concentration of p-Chlorocresol in oral and parenteral veterinary products are 0.1-0.2%. Concentrations are higher (~0.5%) in tropical veterinary products. p-Chlorocresol contains microbial activity against both gram positive and gram negative bacteria and fungi.

References

  1. 1 2 "Creolina: Qué es y para qué sirve" . Retrieved 26 January 2017.
  2. 1 2 Flint, Austin (1888). "A Text-Book of Human Physiology". The Therapeutic Gazette. Retrieved 9 May 2018.
  3. Dujardin-Beaumetz, Georges (1889). "Prophylactic Hygiene Lecture V.- On Disinfectants". The Therapeutic Gazette.
  4. "CREOLIN-PEARSON" (PDF). The Rio News. 2 March 1897.
  5. "Methods of Disinfection Recommended by the Department of Health of the City of New York". The American Journal of Nursing. 1 (8): 546–554. 1901. doi:10.2307/3402121. JSTOR   3402121.
  6. "For Sale at Parcher's Drug Store". The Ellsworth American. 5 May 1915.
  7. Iakhaev, L.I.; Iakhaev, M.L. (24 August 2009). "CREOLIN - OLD, BUT TIME-HONOURED PREPARATION CREOLIN IS OLD BUT ETERNAL". Joint-stock company factory «Veterinary medicines».[ verification needed ]
  8. "PLOUGH ACQUIRES CREOLIN COMPANY; Purchase From Merck & Co. Eighth in Last 2 Years for Drug Producer". New York Times. 11 September 1958.
  9. Zazouli, Mohammad Ali; Homayoun nasab Langroodi, Mahmoud; Ahanjan, Mohmmad; Yazdani Cherati, Jamshid; Islamifar, Masoomeh (10 March 2015). "Efficiency of Some Disinfectants (Cidex, Deconex, and Creolin) against E.coli". Journal of Mazandaran University of Medical Sciences. 24 (122): 137–146. CiteSeerX   10.1.1.889.9176 .
  10. "Trivia 2: creolina". SerTox. Retrieved 26 January 2017.
  11. "Cresol/Cresylic Acid" (PDF). epa.gov. Retrieved 12 July 2018.
  12. Spiller, Henry A.; Quadrani-Kushner, Debra A.; Cleveland, Patricia (January 1993). "A Five Year Evaluation of Acute Exposures to Phenol Disinfectant (26%)". Journal of Toxicology: Clinical Toxicology. 31 (2): 307–313. doi:10.3109/15563659309000397. PMID   8492343. S2CID   29561596.
  13. Judis, Joseph (March 1962). "Studies on the Mechanism of Action of Phenolic Disinfectants I". Journal of Pharmaceutical Sciences. 51 (3): 261–265. doi:10.1002/jps.2600510317. PMID   14452711.
  14. "IDENTIFICATION Name Cresol". DrugBank Online. 12 June 2020.
  15. Shurson, Jerry; Urriola, Pedro (July 2019). "Understanding the vitamin supply chain and relative risk of transmission of foreign animal diseases" (PDF). University of Minnesota.
  16. Juszkiewicz, Małgorzata; Walczak, Marek; Woźniakowski, Grzegorz (1 March 2019). "Characteristics of selected active substances used in disinfectants and their virucidal activity against ASFV". Journal of Veterinary Research. 63 (1): 17–25. doi:10.2478/jvetres-2019-0006. PMC   6458555 . PMID   30989131.
  17. Duque, Francisco L.; Ardila, Carlos M. (October 2011). "Oral myiasis caused by the screwworm Cochliomyia hominivorax treated with subcutaneous ivermectin and creolin: report of six cases after trauma: Oral myiasis caused by the screwworm". Dental Traumatology. 27 (5): 404–407. doi:10.1111/j.1600-9657.2011.01004.x. PMID   21535400.
  18. 1 2 Vearrier, David; Jacobs, Dorian; Greenberg, Michael I. (June 2015). "Phenol Toxicity Following Cutaneous Exposure to Creolin®: A Case Report". Journal of Medical Toxicology. 11 (2): 227–231. doi:10.1007/s13181-014-0440-1. PMC   4469710 . PMID   25326371.
  19. "Creolin to make hair grow longer?". dailycurlz.com. 2013-12-27. Retrieved 31 July 2018.
  20. "creolina hair growth results 8" in 10 months fast". carolina sanchez. Retrieved 31 July 2018.
  21. Hurston, Zora; Neale (1931). "Hoodoo in America". American Folk-lore Society. Retrieved 9 May 2018.