Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration, asexual reproduction, metamorphosis, and the growth and differentiation of stem cells in the adult organism.
An embryo is the initial stage of development for a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male sperm cell. The resulting fusion of these two cells produces a single-celled zygote that undergoes many cell divisions that produce cells known as blastomeres. The blastomeres are arranged as a solid ball that when reaching a certain size, called a morula, takes in fluid to create a cavity called a blastocoel. The structure is then termed a blastula, or a blastocyst in mammals.
Evolutionary developmental biology is a field of biological research that compares the developmental processes of different organisms to infer how developmental processes evolved.
Gastrulation is the stage in the early embryonic development of most animals, during which the blastula, or in mammals the blastocyst, is reorganized into a two-layered or three-layered embryo known as the gastrula. Before gastrulation, the embryo is a continuous epithelial sheet of cells; by the end of gastrulation, the embryo has begun differentiation to establish distinct cell lineages, set up the basic axes of the body, and internalized one or more cell types including the prospective gut.
Somitogenesis is the process by which somites form. Somites are bilaterally paired blocks of paraxial mesoderm that form along the anterior-posterior axis of the developing embryo in segmented animals. In vertebrates, somites give rise to skeletal muscle, cartilage, tendons, endothelium, and dermis.
Gerhard Fankhauser (1901–1981) was an embryologist known for his studies on amphibian development. He was a professor at Princeton from 1931 to 1969, where he retired as the Edwin Grant Conklin Professor of Biology.
Victoria Elizabeth Foe is an American developmental biologist, and Research Professor at the University of Washington's Center for Cell Dynamics. She is known for her work on the development of embryos.
Skeletogenesis is a key morphogenetic event in the embryonic development of vertebrates and is of equal, although transient, importance in the development of the sea urchin, a marine invertebrate. The larval sea urchin does not resemble its adult form, because the sea urchin is an indirect developer, meaning its larva form must undergo metamorphosis to form the juvenile adult. Here, the focus is on skeletogenesis in the sea urchin species Strongylocentrotus purpuratus, as this species has been most thoroughly studied and characterized.
Rosa Susan Penelope Beddington FRS was a British biologist whose career had a major impact on developmental biology.
Septate junctions are intercellular junctions found in invertebrate epithelial cells, appearing as ladder-like structures under electron microscopy. They are thought to provide structural strength and a barrier to solute diffusion through the intercellular space. They are considered somewhat analogous to the (vertebrate) tight junctions; however, tight and septate junctions are different in many ways. Known insect homologues of tight junction components are components of conserved signalling pathways that localize to either adherens junctions, the subapical complex, or the marginal zone. Recent studies show that septate junctions are also identified in the myelinated nerve fibers of the vertebrates.
Norbert Perrimon is a French geneticist and developmental biologist. He is the James Stillman Professor of Developmental Biology in the Department of Genetics at Harvard Medical School, an Investigator at the Howard Hughes Medical Institute, and an Associate of the Broad Institute. He is known for developing a number of techniques for used in genetic research with Drosophila melanogaster, as well as specific substantive contributions to signal transduction, developmental biology and physiology.
Elizabeth Jane Robertson is a British developmental biologist based at the Sir William Dunn School of Pathology, University of Oxford. She is Professor of Developmental Biology at Oxford and a Wellcome Trust Principal Research Fellow. She is best known for her pioneering work in developmental genetics, showing that genetic mutations could be introduced into the mouse germ line by using genetically altered embryonic stem cells. This discovery opened up a major field of experimentation for biologists and clinicians.
Lim-1 is a homeobox transcription factor. This transcription factor is found in adults in the cerebellum, kidneys, and cerebrum, but plays a larger role in development of the fetal head and the female reproductive tract during gestation. During development it is found in the anterior visceral endoderm, is in tissues formed by the primitive streak, and is required in both tissues for head formation. Lim1 is a member of the LIM homeobox gene and encodes a 406 amino acid protein.
Ruth Lehmann is a developmental and cell biologist. She is the Director of the Whitehead Institute for Biomedical Research. She previously was affiliated with the New York University School of Medicine, where she was the Director of the Skirball Institute of Biomolecular Medicine, the Laura and Isaac Perlmutter Professor of Cell Biology, and the Chair of the Department of Cell Biology. Her research focuses on germ cells and embryogenesis.
James Briscoe is a senior group leader at the Francis Crick Institute in London and editor-in-chief of the journal Development.
Vivian Irish is an American evolutionary biologist. She is currently Chair & Eaton Professor of Molecular, Cellular and Developmental Biology and Professor of Ecology and Evolutionary Biology at Yale University. Her research focuses on floral development. She was president of Society for Developmental Biology in 2012 and currently serves as an editor for the journals Developmental Biology and Evolution & Development.
Pauline Schaap is a Dutch cell biologist and evolutionary biologist. She is Professor of Developmental Signalling at the University of Dundee., a corresponding member of the Royal Netherlands Academy of Arts and Sciences, a Fellow of the Royal Society of Biology, and a Fellow of the Royal Society of Edinburgh.
Barry James Thompson is an Australian and British developmental biologist and cancer biologist. Thompson is known for identifying genes, proteins and mechanisms involved in epithelial polarity, morphogenesis and cell signaling via the Wnt and Hippo signaling pathways, which have key roles in human cancer.
Kim Dale FRSB, born in Cheltenham, England on 6 January 1971, is a research scientist based in the Cell and Developmental unit of School of Life Sciences at the University of Dundee, as well as being the Associate Dean International for UoD and the University Academic Regional Lead for ASEAN.
Bernd Fritzsch is a German–American distinguished neurobiologist, professor emeritus, and was the chair of the department of Biology at University of Iowa. He is a fellow of the American Association for the Advancement of Science. He is known for his expertise in comparative molecular neuroembryology, particularly in discovering the molecular evolution and development of sensory cells within the inner ear, including auditory hair cells and neurons. His research identifies critical developmental stages that could facilitate the restoration of hearing abilities.
