KLC1

KLC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3NF1
Identifiers
Aliases	KLC1 , KLC, KNS2, KNS2A, kinesin light chain 1
External IDs	OMIM: 600025 MGI: 107978 HomoloGene: 4056 GeneCards: KLC1
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.33 Start 103,561,896 bp [1] End 103,714,249 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12 F1|12 61.13 cM Start 111,758,849 bp [2] End 111,807,844 bp [2]
RNA expression pattern Bgee Top expressed in Brodmann area 9 cerebellar hemisphere prefrontal cortex superior frontal gyrus dorsolateral prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal motor activity microtubule motor activity GO:0001948 protein binding Cellular component cell projection growth cone GO:0016023 cytoplasmic vesicle cytoplasm microtubule cytoskeleton cytosol kinesin complex membrane Biological process microtubule-based movement antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0022415 viral process stress granule disassembly retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3831	16593
Ensembl	ENSG00000126214	ENSMUSG00000021288
UniProt	Q07866	O88447
RefSeq (mRNA)	NM_182923 NM_001130107 NM_005552	NM_001025358 NM_001025359 NM_001025360 NM_001025361 NM_001025362 NM_001025363 NM_001081959 NM_008450 NM_001361605 NM_001361609 NM_001361610 NM_001361611 NM_001361612 NM_001361613 NM_001361614
RefSeq (protein)	NP_001123579 NP_005543 NP_891553	n/a
Location (UCSC)	Chr 14: 103.56 – 103.71 Mb	Chr 12: 111.76 – 111.81 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene. ^{[5] [6] [7]}

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined. ^[7]

Interactions

KLC1 has been shown to interact with MAPK8IP3, ^[6] KIF5B ^{[8] [9] [10]} and KIF5A. ^{[9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000126214 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021288 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cabeza-Arvelaiz Y, Shih LC, Hardman N, Asselbergs F, Bilbe G, Schmitz A, White B, Siciliano MJ, Lachman LB (Feb 1994). "Cloning and genetic characterization of the human kinesin light-chain (KLC) gene". DNA Cell Biol. 12 (10): 881–92. doi:10.1089/dna.1993.12.881. PMID   8274221.
6. Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS (Jan 2001). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583–94. doi: 10.1016/S0092-8674(00)00162-8 . PMID   11106729.
7. "Entrez Gene: KNS2 kinesin 2".
8. Diefenbach, Russell J; Diefenbach Eve; Douglas Mark W; Cunningham Anthony L (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry. 41 (50): 14906–15. doi:10.1021/bi026417u. ISSN   0006-2960. PMID   12475239.
9. Rahman, A; Friedman D S; Goldstein L S (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". J. Biol. Chem. 273 (25): 15395–403. doi: 10.1074/jbc.273.25.15395 . ISSN   0021-9258. PMID   9624122.
10. Rahman, A; Kamal A; Roberts E A; Goldstein L S (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". J. Cell Biol. 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. ISSN   0021-9525. PMC   2156125 . PMID   10491391.

Further reading

• Miki H, Okada Y, Hirokawa N (2005). "Analysis of the kinesin superfamily: insights into structure and function". Trends Cell Biol. 15 (9): 467–76. doi:10.1016/j.tcb.2005.07.006. PMID   16084724.
• Goedert M, Marsh S, Carter N (1996). "Localization of the human kinesin light chain gene (KNS2) to chromosome 14q32.3 by fluorescence in situ hybridization". Genomics. 32 (1): 173–5. doi:10.1006/geno.1996.0102. PMID   8786116.
• Chernajovsky Y, Brown A, Clark J (1997). "Human kinesin light (beta) chain gene: DNA sequence and functional characterization of its promoter and first exon". DNA Cell Biol. 15 (11): 965–74. doi:10.1089/dna.1996.15.965. PMID   8945637.
• Khodjakov A, Lizunova EM, Minin AA, et al. (1998). "A specific light chain of kinesin associates with mitochondria in cultured cells". Mol. Biol. Cell. 9 (2): 333–43. doi:10.1091/mbc.9.2.333. PMC   25259 . PMID   9450959.
• Rahman A, Friedman DS, Goldstein LS (1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". J. Biol. Chem. 273 (25): 15395–403. doi: 10.1074/jbc.273.25.15395 . PMID   9624122.
• Gyoeva FK, Bybikova EM, Minin AA (2000). "An isoform of kinesin light chain specific for the Golgi complex". J. Cell Sci. 113 (11): 2047–54. doi:10.1242/jcs.113.11.2047. PMID   10806115.
• Kamal A, Stokin GB, Yang Z, et al. (2001). "Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I". Neuron. 28 (2): 449–59. doi: 10.1016/S0896-6273(00)00124-0 . PMID   11144355.
• Verhey KJ, Meyer D, Deehan R, et al. (2001). "Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules". J. Cell Biol. 152 (5): 959–70. doi:10.1083/jcb.152.5.959. PMC   2198804 . PMID   11238452.
• Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (2003). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry. 41 (50): 14906–15. doi:10.1021/bi026417u. PMID   12475239.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Behrends U, Schneider I, Rössler S, et al. (2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries". Int. J. Cancer. 106 (2): 244–51. doi: 10.1002/ijc.11208 . PMID   12800201.
• McCart AE, Mahony D, Rothnagel JA (2004). "Alternatively spliced products of the human kinesin light chain 1 (KNS2) gene". Traffic. 4 (8): 576–80. doi: 10.1034/j.1600-0854.2003.00113.x . PMID   12839500.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Dhaenens CM, Van Brussel E, Schraen-Maschke S, et al. (2005). "Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease". Neurosci. Lett. 368 (3): 290–2. doi:10.1016/j.neulet.2004.07.040. PMID   15364413. S2CID   25039113.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Pernigo S; Lamprecht A; Steiner RA; Dodding MP (2013). "Structural basis for kinesin-1:cargo recognition". Science. 340 (6130): 356–359. Bibcode:2013Sci...340..356P. doi:10.1126/science.1234264. PMC   3693442 . PMID   23519214.