KLK2

Last updated
KLK2
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases KLK2 , KLK2A2, hGK-1, hK2, kallikrein related peptidase 2
External IDs OMIM: 147960 HomoloGene: 124422 GeneCards: KLK2
Orthologs
SpeciesHumanMouse
Entrez

3817

n/a

Ensembl

ENSG00000167751

n/a

UniProt

P20151

n/a

RefSeq (mRNA)

NM_001002231
NM_001002232
NM_001256080
NM_005551

n/a

RefSeq (protein)

NP_001002231
NP_001243009
NP_005542

n/a

Location (UCSC) Chr 19: 50.86 – 50.88 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue. [3] [4] [5] [6]

Contents

Related Research Articles

Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases. These genes are localised to chromosome 19q13, forming the largest contiguous cluster of proteases within the human genome. Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation.

<span class="mw-page-title-main">CD59</span> Mammalian protein found in Homo sapiens

CD59 glycoprotein, also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. It is an LU domain and belongs to the LY6/uPAR/alpha-neurotoxin protein family.

<span class="mw-page-title-main">CAPN10</span> Protein-coding gene in the species Homo sapiens

Calpain-10 is a protein that in humans is encoded by the CAPN10 gene.

<span class="mw-page-title-main">KLK1</span> Protein-coding gene in the species Homo sapiens

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family.

<span class="mw-page-title-main">CCR10</span> Protein-coding gene in the species Homo sapiens

C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.

<span class="mw-page-title-main">GPR4</span> Protein-coding gene in the species Homo sapiens

G-protein coupled receptor 4 is a protein that in humans is encoded by the GPR4 gene.

<span class="mw-page-title-main">KLK6</span> Protein-coding gene in the species Homo sapiens

Kallikrein-6 is a protein that in humans is encoded by the KLK6 gene. Kallikrein-6 is also referred to as neurosin, protease M, hK6, or zyme. It is a 223 amino acid sequence, derived from its 244 original form, which contains a 16 residue presignal and 5 residue activation peptide.

<span class="mw-page-title-main">KLK10</span> Protein-coding gene in the species Homo sapiens

Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.

<span class="mw-page-title-main">Kallikrein-5</span> Protein-coding gene in the species Homo sapiens

Kallikrein-5, formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. Alternative splicing results in multiple transcript variants encoding the same protein.

<span class="mw-page-title-main">KLK4</span> Mammalian protein found in Homo sapiens

Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.

<span class="mw-page-title-main">KLK11</span> Protein-coding gene in the species Homo sapiens

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.

<span class="mw-page-title-main">SEMG2</span> Protein-coding gene in the species Homo sapiens

Semenogelin-2 is a protein that in humans is encoded by the SEMG2 gene.

<span class="mw-page-title-main">SERPINB6</span> Protein-coding gene in the species Homo sapiens

Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.

<span class="mw-page-title-main">KLK7</span> Protein-coding gene in the species Homo sapiens

Kallikrein-related peptidase 7 (KLK7) is a serine protease that in humans is encoded by the KLK7 gene. KLK7 was initially purified from the epidermis and characterised as stratum corneum chymotryptic enzyme (SCCE). It was later identified as the seventh member of the human kallikrein family, which includes fifteen homologous serine proteases located on chromosome 19 (19q13).

<span class="mw-page-title-main">KLK13</span> Gene of the species Homo sapiens

Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene.

<span class="mw-page-title-main">KLK8</span> Protein-coding gene in the species Homo sapiens

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.

<span class="mw-page-title-main">KLK14</span> Protein-coding gene in the species Homo sapiens

Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.

<span class="mw-page-title-main">KLK15</span> Protein-coding gene in the species Homo sapiens

Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.

<span class="mw-page-title-main">KLK12</span> Protein-coding gene in the species Homo sapiens

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.

<span class="mw-page-title-main">KLK9</span> Protein-coding gene in the species Homo sapiens

Kallikrein-related peptidase 9 also known as KLK9 is an enzyme which in humans is encoded by the KLK9 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000167751 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ Riegman PH, Vlietstra RJ, Klaassen P, van der Korput JA, Geurts van Kessel A, Romijn JC, Trapman J (May 1989). "The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19". FEBS Lett. 247 (1): 123–126. doi: 10.1016/0014-5793(89)81253-0 . PMID   2468530. S2CID   37763337.
  4. ↑ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–641. doi:10.1515/BC.2006.082. PMID   16800724. S2CID   436200.
  5. ↑ Diamandis EP, Deperthes D, Lundwall Å (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–636. doi:10.1515/BC.2006.081. PMID   16800723. S2CID   83910246.
  6. ↑ "Entrez Gene: KLK2 Kallikrein-related peptidase 2".

Further reading

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