RCC1

RCC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A12, 1I2M, 5E1O, 5E2A, 5E1M, 5E2B, 5E1D, 5E1B
Identifiers
Aliases	RCC1 , CHC1, RCC1-I, SNHG3-regulator of chromosome condensation 1
External IDs	OMIM: 179710 MGI: 1913989 HomoloGene: 55567 GeneCards: RCC1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	28,539,300 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,080,916 bp
RNA expression pattern
	Top expressed in
	sperm; ; islet of Langerhans; ; ganglionic eminence; ; stromal cell of endometrium; ; oocyte; ; rectum; ; lymph node; ; minor salivary gland; ; monocyte; ; secondary oocyte;
	Top expressed in
	spermatocyte; ; yolk sac; ; spermatid; ; somite; ; primitive streak; ; thymus; ; morula; ; lip; ; ankle joint; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding ; guanyl-nucleotide exchange factor activity ; histone binding ; chromatin binding ; protein binding ; nucleosomal DNA binding ; nucleosome binding ; sulfate binding ; protein heterodimerization activity ;
Cellular component	cytoplasm ; nuclear membrane ; nucleoplasm ; condensed nuclear chromosome ; nucleus ; chromatin ; chromosome ; protein-containing complex ;
Biological process	chromosome segregation ; G1 phase ; mitotic spindle organization ; cell division ; spindle assembly ; cell cycle ; viral process ; regulation of mitotic nuclear division ; protein heterotetramerization ; regulation of molecular function ; G1/S transition of mitotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	1104
	100088
	ENSG00000180198
	ENSMUSG00000028896
	P18754 ; Q5T081
	Q8VE37
NM_001048194 ; NM_001048195 ; NM_001048199 ; NM_001269 ; NM_001381865 ;
	NM_001381866
	NM_001197082 ; NM_133878
NP_001041659 ; NP_001041660 ; NP_001041664 ; NP_001260 ; NP_001368794 ;
	NP_001368795 ; NP_001041664.1 ; NP_001260.1
	NP_001184011 ; NP_598639
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein.^[5]

Interactions

RCC1 has been shown to interact with RANBP3 ^[6]^[7] and Ran (biology).^[8]^[9]^[10]^[11]

Related Research Articles

Ran also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.

<span class="mw-page-title-main">Guanine nucleotide exchange factor</span> Proteins which remove GDP from GTPases

Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity. Some GEFs can activate multiple GTPases while others are specific to a single GTPase.

RAN binding protein 2 (RANBP2) is protein which in humans is encoded by the RANBP2 gene. It is also known as nucleoporin 358 (Nup358) since it is a member nucleoporin family that makes up the nuclear pore complex. RanBP2 has a mass of 358 kDa.

G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.

Interleukin enhancer-binding factor 3 is a protein that in humans is encoded by the ILF3 gene.

Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. It is involved in calcium-triggered exocytosis in neurons.

Rho guanine nucleotide exchange factor TIAM1 is a protein that in humans is encoded by the TIAM1 gene.

Rap guanine nucleotide exchange factor 3 also known as exchange factor directly activated by cAMP 1 (EPAC1) or cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) is a protein that in humans is encoded by the RAPGEF3 gene.

Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the RANGAP1 gene.

Dock180, also known as DOCK1, is a large protein involved in intracellular signalling networks. It is the mammalian ortholog of the C. elegans protein CED-5 and belongs to the DOCK family of Guanine nucleotide exchange factors (GEFs).

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene. This protein is also called RhoGEF1 or p115-RhoGEF.

RhoG is a small monomeric GTP-binding protein, and is an important component of many intracellular signalling pathways. It is a member of the Rac subfamily of the Rho family of small G proteins and is encoded by the gene RHOG.

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.

Triple functional domain protein is a protein that in humans is encoded by the TRIO gene.

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.

RCC1 and BTB domain-containing protein 1 is a protein that in humans is encoded by the RCBTB1 gene.

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.

Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.

RCC1 and BTB domain-containing protein 2 is a protein that in humans is encoded by the RCBTB2 gene.

Mary C. Dasso is an American biochemist known for research on chromosome segregation and the discovery of Ran GTPase. She is the acting scientific director of the division of intramural research and a senior investigator in the section on cell cycle regulation at the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000180198 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028896 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: RCC1 Regulator of chromosome condensation 1".
↑ Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". The Journal of Biological Chemistry. 277 (20): 17385–8. doi: 10.1074/jbc.C100620200 . PMID 11932251.
↑ Mueller L, Cordes VC, Bischoff FR, Ponstingl H (May 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Letters. 427 (3): 330–6. doi: 10.1016/S0014-5793(98)00459-1 . PMID 9637251.
↑ Steggerda SM, Paschal BM (July 2000). "The mammalian Mog1 protein is a guanine nucleotide release factor for Ran". The Journal of Biological Chemistry. 275 (30): 23175–80. doi: 10.1074/jbc.C000252200 . PMID 10811801.
↑ Renault L, Kuhlmann J, Henkel A, Wittinghofer A (April 2001). "Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)". Cell. 105 (2): 245–55. doi: 10.1016/S0092-8674(01)00315-4 . PMID 11336674. S2CID 12827419.
↑ Azuma Y, Renault L, García-Ranea JA, Valencia A, Nishimoto T, Wittinghofer A (June 1999). "Model of the ran-RCC1 interaction using biochemical and docking experiments". Journal of Molecular Biology. 289 (4): 1119–30. doi:10.1006/jmbi.1999.2820. PMID 10369786.
↑ Ren M, Villamarin A, Shih A, Coutavas E, Moore MS, LoCurcio M, Clarke V, Oppenheim JD, D'Eustachio P, Rush MG (April 1995). "Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing". Molecular and Cellular Biology. 15 (4): 2117–24. doi:10.1128/MCB.15.4.2117. PMC 230439 . PMID 7891706.

Furuno N, Nakagawa K, Eguchi U, Ohtsubo M, Nishimoto T, Soeda E, Ohtubo M (October 1991). "Complete nucleotide sequence of the human RCC1 gene involved in coupling between DNA replication and mitosis". Genomics. 11 (2): 459–61. doi:10.1016/0888-7543(91)90156-9. PMID 1769659.
Bischoff FR, Ponstingl H (November 1991). "Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1". Nature. 354 (6348): 80–2. Bibcode:1991Natur.354...80B. doi:10.1038/354080a0. PMID 1944575. S2CID 4346596.
Bischoff FR, Ponstingl H (December 1991). "Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide". Proceedings of the National Academy of Sciences of the United States of America. 88 (23): 10830–4. Bibcode:1991PNAS...8810830B. doi: 10.1073/pnas.88.23.10830 . PMC 53025 . PMID 1961752.
Bischoff FR, Maier G, Tilz G, Ponstingl H (November 1990). "A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation". Proceedings of the National Academy of Sciences of the United States of America. 87 (21): 8617–21. Bibcode:1990PNAS...87.8617B. doi: 10.1073/pnas.87.21.8617 . PMC 55008 . PMID 2236072.
Ohtsubo M, Okazaki H, Nishimoto T (October 1989). "The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA". The Journal of Cell Biology. 109 (4 Pt 1): 1389–97. doi:10.1083/jcb.109.4.1389. PMC 2115805 . PMID 2677018.
Ohtsubo M, Kai R, Furuno N, Sekiguchi T, Sekiguchi M, Hayashida H, Kuma K, Miyata T, Fukushige S, Murotsu T (August 1987). "Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation". Genes & Development. 1 (6): 585–93. doi: 10.1101/gad.1.6.585 . PMID 3678831.
Hayashi N, Yokoyama N, Seki T, Azuma Y, Ohba T, Nishimoto T (June 1995). "RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4". Molecular & General Genetics. 247 (6): 661–9. doi:10.1007/BF00290397. PMID 7616957. S2CID 24266692.
Nishimoto T, Seino H, Seki N, Hori TA (October 1994). "The human CHC1 gene encoding RCC1 (regulator of chromosome condensation) (CHC1) is localized to human chromosome 1p36.1". Genomics. 23 (3): 719–21. doi:10.1006/geno.1994.1570. PMID 7851910.
Miyabashira J, Sekiguchi T, Nishimoto T (August 1994). "Mammalian cells have two functional RCC1 proteins produced by alternative splicing". Journal of Cell Science. 107 ( Pt 8) (8): 2203–8. doi:10.1242/jcs.107.8.2203. PMID 7983178.
Noguchi E, Hayashi N, Azuma Y, Seki T, Nakamura M, Nakashima N, Yanagida M, He X, Mueller U, Sazer S, Nishimoto T (October 1996). "Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1". The EMBO Journal. 15 (20): 5595–605. doi:10.1002/j.1460-2075.1996.tb00944.x. PMC 452304 . PMID 8896453.
Renault L, Nassar N, Vetter I, Becker J, Klebe C, Roth M, Wittinghofer A (March 1998). "The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller". Nature. 392 (6671): 97–101. Bibcode:1998Natur.392...97R. doi:10.1038/32204. PMID 9510255. S2CID 4344559.
Renault L, Nassar N, Wittinghofer A, Roth M, Vetter IR (January 1999). "Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation". Acta Crystallographica. Section D, Biological Crystallography. 55 (Pt 1): 272–5. doi:10.1107/S0907444998007768. PMID 10089422.
Azuma Y, Renault L, García-Ranea JA, Valencia A, Nishimoto T, Wittinghofer A (June 1999). "Model of the ran-RCC1 interaction using biochemical and docking experiments". Journal of Molecular Biology. 289 (4): 1119–30. doi:10.1006/jmbi.1999.2820. PMID 10369786.
Talcott B, Moore MS (April 2000). "The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, karyopherin alpha3/Qip". The Journal of Biological Chemistry. 275 (14): 10099–104. doi: 10.1074/jbc.275.14.10099 . PMID 10744690.
Nemergut ME, Macara IG (May 2000). "Nuclear import of the ran exchange factor, RCC1, is mediated by at least two distinct mechanisms". The Journal of Cell Biology. 149 (4): 835–50. doi:10.1083/jcb.149.4.835. PMC 2174574 . PMID 10811825.
Fontoura BM, Blobel G, Yaseen NR (October 2000). "The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". The Journal of Biological Chemistry. 275 (40): 31289–96. doi: 10.1074/jbc.M004651200 . PMID 10875935.
Freire J, Covelo G, Sarandeses C, Díaz-Jullien C, Freire M (2001). "Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha". Biochemistry and Cell Biology. 79 (2): 123–31. doi:10.1139/bcb-79-2-123. PMID 11310559.
Renault L, Kuhlmann J, Henkel A, Wittinghofer A (April 2001). "Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)". Cell. 105 (2): 245–55. doi: 10.1016/S0092-8674(01)00315-4 . PMID 11336674. S2CID 12827419.
Nemergut ME, Mizzen CA, Stukenberg T, Allis CD, Macara IG (May 2001). "Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B". Science. 292 (5521): 1540–3. Bibcode:2001Sci...292.1540N. doi:10.1126/science.292.5521.1540. PMID 11375490.
Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". The Journal of Biological Chemistry. 277 (20): 17385–8. doi: 10.1074/jbc.C100620200 . PMID 11932251.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000180198 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028896 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: RCC1 Regulator of chromosome condensation 1".

[pmid11932251-6] Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". The Journal of Biological Chemistry. 277 (20): 17385–8. doi: 10.1074/jbc.C100620200 . PMID 11932251.

[pmid9637251-7] Mueller L, Cordes VC, Bischoff FR, Ponstingl H (May 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Letters. 427 (3): 330–6. doi: 10.1016/S0014-5793(98)00459-1 . PMID 9637251.

[pmid10811801-8] Steggerda SM, Paschal BM (July 2000). "The mammalian Mog1 protein is a guanine nucleotide release factor for Ran". The Journal of Biological Chemistry. 275 (30): 23175–80. doi: 10.1074/jbc.C000252200 . PMID 10811801.

[pmid11336674-9] Renault L, Kuhlmann J, Henkel A, Wittinghofer A (April 2001). "Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)". Cell. 105 (2): 245–55. doi: 10.1016/S0092-8674(01)00315-4 . PMID 11336674. S2CID 12827419.

[pmid10369786-10] Azuma Y, Renault L, García-Ranea JA, Valencia A, Nishimoto T, Wittinghofer A (June 1999). "Model of the ran-RCC1 interaction using biochemical and docking experiments". Journal of Molecular Biology. 289 (4): 1119–30. doi:10.1006/jmbi.1999.2820. PMID 10369786.

[pmid7891706-11] Ren M, Villamarin A, Shih A, Coutavas E, Moore MS, LoCurcio M, Clarke V, Oppenheim JD, D'Eustachio P, Rush MG (April 1995). "Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing". Molecular and Cellular Biology. 15 (4): 2117–24. doi:10.1128/MCB.15.4.2117. PMC 230439 . PMID 7891706.

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RCC1

Contents

Interactions

Related Research Articles

References

Further reading