Carole Goble

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Carole Goble

Carole Goble by Rob Whitrow (15682291039).jpg
Carole Goble by Rob Whitrow
Born
Carole Anne Goble

(1961-04-10) 10 April 1961 (age 63) [1]
NationalityBritish
Education Maidstone School for Girls
Alma mater University of Manchester
Known for
Spouse
Ian Cottam
(m. 2003)
[6]
Awards
Scientific career
Fields
Institutions
Academic advisors
Website manchester.ac.uk/research/carole.goble

Carole Anne Goble, CBE FREng FBCS [12] (born 10 April 1961) [1] is a British academic who is Professor of Computer Science at the University of Manchester. [13] She is principal investigator (PI) of the myGrid, [14] BioCatalogue [15] and myExperiment [16] projects and co-leads the Information Management Group (IMG) with Norman Paton. [17]

Contents

Education

Goble was educated at Maidstone School for Girls, which is now called Invicta Grammar School. [1] Her academic career has been spent at the Department of Computer Science, where she gained her Bachelor of Science degree in computing and information systems from 1979 to 1982. [18]

Research and career

Her current research interests [8] [19] [20] include grid computing, the semantic grid, [21] the Semantic Web, ontologies, [22] [23] e-Science, medical informatics, [24] bioinformatics, and Research Objects. She applies advances in knowledge technologies and workflow systems [25] to solve information management problems for life scientists and other scientific disciplines. [26] She has successfully secured funding from the European Union, the Defense Advanced Research Projects Agency (DARPA) in the United States and UK funding agencies including the Engineering and Physical Sciences Research Council (EPSRC), [27] Biotechnology and Biological Sciences Research Council (BBSRC), [28] Economic and Social Research Council (ESRC), Medical Research Council (United Kingdom) (MRC), the Department of Health, the Open Middleware Infrastructure Institute and the Department of Trade and Industry. [29]

Her work has been published in leading peer reviewed scientific journals including Nucleic Acids Research , [3] Bioinformatics , [30] [31] IEEE Computer , [9] the Journal of Biomedical Semantics , [32] Briefings in Bioinformatics , [33] [34] Artificial Intelligence in Medicine, [24] the Pacific Symposium on Biocomputing conference, [22] the International Journal of Cooperative Information Systems , the Journal of Biomedical Informatics , [35] Nature Genetics [36] and Drug Discovery Today . [37] [38] [39] [40] [41] [42]

Goble joined the University of Manchester in 1985, and was appointed to a chair in 2000. [43] She is an editorial board member of IEEE Internet Computing , GigaScience , and the International Journal of Web Services Research , and served as the editor-in-chief of Elsevier's Journal of Web Semantics from 2003 to 2008. [44]

Goble serves on several committees, including the advisory committees of the Science and Technology Facilities Council Physical and Life Sciences advisory committee, the Netherlands Bioinformatics Centre and the European Grid Infrastructure committee.

She was appointed to the Biotechnology and Biological Sciences Research Council on 13 June 2013. [10]

She has served on the Engineering and Physical Sciences Research Council Technical Opportunities Panel, the Semantic Web Science Association, the British Library's Content Strategy Advisory Board and the Research Councils UK e-Science Steering Committee. She co-founded Cerebra, [45] an early spin-off company to exploit Semantic Web technologies, which has been sold.

Awards and honours

Carole Goble at Buckingham Palace with Douglas Kell after receiving her CBE. Carole Goble (CBE) and Douglas Kell (CBE) (13711397785).jpg
Carole Goble at Buckingham Palace with Douglas Kell after receiving her CBE.

Goble was recipient of the first Jim Gray e-Science Award in December 2008. Tony Hey, corporate vice-president of Microsoft External Research, who sponsored the award, said Goble was chosen for the award because of her work to help scientists do data-intensive science through the Apache Taverna.

Her work has won best paper awards at the 3rd IEEE International Conference on e-Science and Grid Computing (2007) and the 11th ACM International Conference on Hypertext. [46] In 2002 she was honoured by Sun Microsystems for her significant achievements in advancing life science computing. She has given keynotes in many forums, including international conferences on digital curation, e-social science, grid computing, Intelligent Systems for Molecular Biology, [31] [47] Pacific Symposium on Biocomputing, [22] hypertext and hypermedia, Bioinformatics Open Source Conference (BOSC), [5] artificial intelligence, [48] systems biology, discovery science, the Semantic Web, International World Wide Web Conference [49] and medical informatics.

Goble was appointed Commander of the Order of the British Empire (CBE) in the 2014 New Year Honours for services to science. [50]

She was elected a Fellow of the Royal Academy of Engineering (FREng) in 2010. [51] [12] In January 2018 Goble was awarded the degree of Doctorem (honoris causa) by Maastricht University. [52]

Related Research Articles

Semantic similarity is a metric defined over a set of documents or terms, where the idea of distance between items is based on the likeness of their meaning or semantic content as opposed to lexicographical similarity. These are mathematical tools used to estimate the strength of the semantic relationship between units of language, concepts or instances, through a numerical description obtained according to the comparison of information supporting their meaning or describing their nature. The term semantic similarity is often confused with semantic relatedness. Semantic relatedness includes any relation between two terms, while semantic similarity only includes "is a" relations. For example, "car" is similar to "bus", but is also related to "road" and "driving".

The Open Biological and Biomedical Ontologies (OBO) Foundry is a group of people dedicated to build and maintain ontologies related to the life sciences. The OBO Foundry establishes a set of principles for ontology development for creating a suite of interoperable reference ontologies in the biomedical domain. Currently, there are more than a hundred ontologies that follow the OBO Foundry principles.

The myGrid consortium produces and uses a suite of tools design to “help e-Scientists get on with science and get on with scientists”. The tools support the creation of e-laboratories and have been used in domains as diverse as systems biology, social science, music, astronomy, multimedia and chemistry.

<span class="mw-page-title-main">Apache Taverna</span>

Apache Taverna was an open source software tool for designing and executing workflows, initially created by the myGrid project under the name Taverna Workbench, then a project under the Apache incubator. Taverna allowed users to integrate many different software components, including WSDL SOAP or REST Web services, such as those provided by the National Center for Biotechnology Information, the European Bioinformatics Institute, the DNA Databank of Japan (DDBJ), SoapLab, BioMOBY and EMBOSS. The set of available services was not finite and users could import new service descriptions into the Taverna Workbench.

<span class="mw-page-title-main">Robert Stevens (scientist)</span>

Robert David Stevens is a professor of bio-health informatics. and former Head of Department of Computer Science at The University of Manchester

<span class="mw-page-title-main">Alan Rector</span> British computer scientist

Alan L. Rector is a Professor of Medical Informatics in the Department of Computer Science at the University of Manchester in the UK.

<span class="mw-page-title-main">Frank van Harmelen</span>

Frank van Harmelen is a Dutch computer scientist and professor in Knowledge Representation & Reasoning in the AI department at the Vrije Universiteit Amsterdam. He was scientific director of the LarKC project (2008-2011), "aiming to develop the Large Knowledge Collider, a platform for very large scale semantic web reasoning."

The National Centre for Text Mining (NaCTeM) is a publicly funded text mining (TM) centre. It was established to provide support, advice and information on TM technologies and to disseminate information from the larger TM community, while also providing services and tools in response to the requirements of the United Kingdom academic community.

myExperiment is a social web site for researchers sharing research objects such as scientific workflows.

The BioCatalogue is a curated catalogue of Life Science Web Services. The BioCatalogue was launched in June 2009 at the Intelligent Systems for Molecular Biology Conference. The project is a collaboration between the myGrid project at the University of Manchester led by Carole Goble and the European Bioinformatics Institute led by Rodrigo Lopez. It is funded by the Biotechnology and Biological Sciences Research Council.

Jun'ichi Tsujii is a Japanese computer scientist specializing in natural language processing and text mining, particularly in the field of biology and bioinformatics.

<span class="mw-page-title-main">Ulrike Sattler</span>

Ulrike M. Sattler is a professor of computer science in the information management group of the Department of Computer Science at the University of Manchester and a visiting professor at the University of Oslo.

<span class="mw-page-title-main">Terri Attwood</span> British bioinformatics researcher

Teresa K. Attwood is a professor of Bioinformatics in the Department of Computer Science and School of Biological Sciences at the University of Manchester and a visiting fellow at the European Bioinformatics Institute (EMBL-EBI). She held a Royal Society University Research Fellowship at University College London (UCL) from 1993 to 1999 and at the University of Manchester from 1999 to 2002.

A bioinformatics workflow management system is a specialized form of workflow management system designed specifically to compose and execute a series of computational or data manipulation steps, or a workflow, that relate to bioinformatics.

<span class="mw-page-title-main">Andy Brass</span>

Andrew M. Brass is a Professor of Bioinformatics at the University of Manchester in the Department of Computer Science and Faculty of Life Sciences.

Norman William Paton is a Professor in the Department of Computer Science at the University of Manchester in the UK where he co-leads the Information Management Group (IMG) with Carole Goble.

<span class="mw-page-title-main">OnlineHPC</span>

The OnlineHPC was a free public web service that supplied tools to deal with high performance computers and online workflow editor. OnlineHPC allowed users to design and execute workflows using the online workflow designer and to work with high performance computers – clusters and clouds. Access to high performance resources was available as directly from the service user interface, as from workflow components. The workflow engine of the OnlineHPC service was Taverna as traditionally used for scientific workflow execution in such domains, as bioinformatics, cheminformatics, medicine, astronomy, social science, music, and digital preservation.

Open PHACTS was a European initiative public–private partnership between academia, publishers, enterprises, pharmaceutical companies and other organisations working to enable better, cheaper and faster drug discovery. It has been funded by the Innovative Medicines Initiative, selected as part of three projects to "design methods for common standards and sharing of data for more efficient drug development and patient treatment in the future".

Enhanced publications or enhanced ebooks are a form of electronic publishing for the dissemination and sharing of research outcomes, whose first formal definition can be tracked back to 2009. As many forms of digital publications, they typically feature a unique identifier and descriptive metadata information. Unlike traditional digital publications, enhanced publications are often tailored to serve specific scientific domains and are generally constituted by a set of interconnected parts corresponding to research assets of several kinds and to textual descriptions of the research. The nature and format of such parts and of the relationships between them, depends on the application domain and may largely vary from case to case.

In computing, a Research Object is a method for the identification, aggregation and exchange of scholarly information on the Web. The primary goal of the research object approach is to provide a mechanism to associate related resources about a scientific investigation so that they can be shared using a single identifier. As such, research objects are an advanced form of Enhanced publication.

References

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  2. Groth, P.; Loizou, A.; Gray, A. J. G.; Goble, C.; Harland, L.; Pettifer, S. (2014). "API-centric Linked Data integration: The Open PHACTS Discovery Platform case study" (PDF). Web Semantics: Science, Services and Agents on the World Wide Web. 29: 12–18. doi:10.1016/j.websem.2014.03.003.
  3. 1 2 Hull, D.; Wolstencroft, K.; Stevens, R.; Goble, C. A.; Pocock, M. R.; Li, P.; Oinn, T. (2006). "Taverna: A tool for building and running workflows of services". Nucleic Acids Research . 34 (Web Server issue): W729–W732. doi:10.1093/nar/gkl320. PMC   1538887 . PMID   16845108. Open Access logo PLoS transparent.svg
  4. Wolstencroft, K.; Haines, R.; Fellows, D.; Williams, A.; Withers, D.; Owen, S.; Soiland-Reyes, S.; Dunlop, I.; Nenadic, A.; Fisher, P.; Bhagat, J.; Belhajjame, K.; Bacall, F.; Hardisty, A.; Nieva De La Hidalga, A.; Balcazar Vargas, M. P.; Sufi, S.; Goble, C. (2013). "The Taverna workflow suite: Designing and executing workflows of Web Services on the desktop, web or in the cloud". Nucleic Acids Research. 41 (Web Server issue): W557–W561. doi:10.1093/nar/gkt328. PMC   3692062 . PMID   23640334.
  5. 1 2 http://www.slideshare.net/dullhunk/the-seven-deadly-sins-of-bioinformatics/ The Seven deadly sins of Bioinformatics, talk by Carole Goble at BOSC and Intelligent Systems for Molecular Biology 2007
  6. 1 2 "Global Goble, profile of Carole in the April 2009 edition of Manchester UniLife" (PDF). University of Manchester. Retrieved 4 July 2011.
  7. "2012 Karen Sparck Jones lecture by Professor Carole Goble". Archived from the original on 5 October 2013.
  8. 1 2 Carole Goble publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  9. 1 2 Gil, Y.; Deelman, E.; Ellisman, M.; Fahringer, T.; Fox, G.; Gannon, D.; Goble, C.; Livny, M.; Moreau, L.; Myers, J. (2007). "Examining the Challenges of Scientific Workflows" (PDF). Computer. 40 (12): 24–32. doi:10.1109/MC.2007.421. S2CID   10534913.
  10. 1 2 "13 June 2013 – BBSRC announces new Council members". Archived from the original on 29 June 2013.
  11. Rector, A. L.; Nowlan, W. A.; Kay, S.; Goble, C. A.; Howkins, T. J. (1993). "A framework for modelling the electronic medical record". Methods of Information in Medicine. 32 (2): 109–119. doi:10.1055/s-0038-1634902. PMID   8321129. S2CID   16532244.
  12. 1 2 "List of Fellows". Archived from the original on 8 June 2016. Retrieved 16 October 2014.
  13. "Carole Goble introduction on public-semweb-lifesci mailing list". World Wide Web Consortium (W3C). Archived from the original on 20 October 2014.
    - "Prof Carole Goble, research profile – personal details (The University of Manchester)" . Retrieved 4 July 2011.
  14. Stevens, R.; Robinson, A.; Goble, C. (2003). "MyGrid: Personalised bioinformatics on the information grid". Bioinformatics. 19 (Suppl 1): i302–i304. doi: 10.1093/bioinformatics/btg1041 . PMID   12855473.
  15. Bhagat, J.; Tanoh, F.; Nzuobontane, E.; Laurent, T.; Orlowski, J.; Roos, M.; Wolstencroft, K.; Aleksejevs, S.; Stevens, R.; Pettifer, S.; Lopez, R.; Goble, C. A. (2010). "BioCatalogue: A universal catalogue of web services for the life sciences". Nucleic Acids Research. 38 (Web Server issue): W689–W694. doi:10.1093/nar/gkq394. PMC   2896129 . PMID   20484378.
  16. Goble, C. A.; Bhagat, J.; Aleksejevs, S.; Cruickshank, D.; Michaelides, D.; Newman, D.; Borkum, M.; Bechhofer, S.; Roos, M.; Li, P.; De Roure, D. (2010). "MyExperiment: A repository and social network for the sharing of bioinformatics workflows". Nucleic Acids Research. 38 (Web Server issue): W677–W682. doi:10.1093/nar/gkq429. PMC   2896080 . PMID   20501605.
  17. "Professor Carole Goble CBE FREng FBCS". Archived from the original on 12 March 2014.
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  18. Carole Goble: Democratizing Informatics for the ‘Long Tail’ Scientist, BioITWorld, 31 March 31 April 2011
  19. Carole Goble at DBLP Bibliography Server OOjs UI icon edit-ltr-progressive.svg
  20. Carole Goble publications from Europe PubMed Central
  21. Corcho, O.; Alper, P.; Kotsiopoulos, I.; Missier, P.; Bechhofer, S.; Goble, C. (2006). "An overview of S-OGSA: A Reference Semantic Grid Architecture". Web Semantics: Science, Services and Agents on the World Wide Web. 4 (2): 102–115. doi:10.1016/j.websem.2006.03.001. S2CID   1386051.
  22. 1 2 3 Wroe, C. J.; Stevens, R.; Goble, C. A.; Ashburner, M. (2003). "A methodology to migrate the gene ontology to a description logic environment using DAML+OIL". Pacific Symposium on Biocomputing: 624–635. CiteSeerX   10.1.1.121.5880 . doi:10.1142/9789812776303_0058. ISBN   978-981-238-217-7. PMID   12603063.
  23. Bechhofer, S.; Horrocks, I.; Goble, C.; Stevens, R. (2001). "OilEd: A Reason-able Ontology Editor for the Semantic Web". KI 2001: Advances in Artificial Intelligence. Lecture Notes in Computer Science. Vol. 2174. pp. 396–408. doi:10.1007/3-540-45422-5_28. ISBN   978-3-540-42612-7.
    - Lord, P. W.; Stevens, R. D.; Brass, A.; Goble, C. A. (2003). "Investigating semantic similarity measures across the Gene Ontology: The relationship between sequence and annotation". Bioinformatics. 19 (10): 1275–1283. doi: 10.1093/bioinformatics/btg153 . PMID   12835272.
  24. 1 2 Rector, A.; Bechhofer, S.; Goble, C.; Horrocks, I.; Nowlan, W.; Solomon, W. (1997). "The GRAIL concept modelling language for medical terminology" (PDF). Artificial Intelligence in Medicine. 9 (2): 139–171. doi:10.1016/S0933-3657(96)00369-7. PMID   9040895.
  25. Hettne, K.; Soiland-Reyes, S.; Klyne, G.; Belhajjame, K.; Gamble, M.; Bechhofer, S.; Roos, M.; Corcho, O. (2012). "Workflow forever". Proceedings of the 4th International Workshop on Semantic Web Applications and Tools for the Life Sciences - SWAT4LS '11 (PDF). p. 36. doi:10.1145/2166896.2166909. ISBN   9781450310765. S2CID   36849866.
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  27. "UK Government research grants awarded to Carole Goble". Research Councils UK. Archived from the original on 22 February 2015.
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  30. Wolstencroft, K.; Owen, S.; Horridge, M.; Krebs, O.; Mueller, W.; Snoep, J. L.; Du Preez, F.; Goble, C. (2011). "RightField: Embedding ontology annotation in spreadsheets". Bioinformatics. 27 (14): 2021–2022. doi:10.1093/bioinformatics/btr312. PMID   21622664.
  31. 1 2 Stevens, R. D.; Tipney, H. J.; Wroe, C. J.; Oinn, T. M.; Senger, M.; Lord, P. W.; Goble, C. A.; Brass, A.; Tassabehji, M. (2004). "Exploring Williams-Beuren syndrome using myGrid". Bioinformatics. 20: i303–i310. CiteSeerX   10.1.1.1.7196 . doi:10.1093/bioinformatics/bth944. PMID   15262813.
  32. Hettne, K. M.; Dharuri, H; Zhao, J; Wolstencroft, K; Belhajjame, K; Soiland-Reyes, S; Mina, E; Thompson, M; Cruickshank, D; Verdes-Montenegro, L; Garrido, J; De Roure, D; Corcho, O; Klyne, G; Van Schouwen, R; 't Hoen, P. A.; Bechhofer, S; Goble, C; Roos, M (2014). "Structuring research methods and data with the research object model: Genomics workflows as a case study". Journal of Biomedical Semantics. 5 (1): 41. doi: 10.1186/2041-1480-5-41 . PMC   4177597 . PMID   25276335.
  33. Goble, C.; Stevens, R.; Hull, D.; Wolstencroft, K.; Lopez, R. (2008). "Data curation + process curation=data integration + science". Briefings in Bioinformatics. 9 (6): 506–517. doi: 10.1093/bib/bbn034 . PMID   19060304.
    - Stevens, R.; Zhao, J.; Goble, C. (2007). "Using provenance to manage knowledge of in Silico experiments". Briefings in Bioinformatics. 8 (3): 183–194. doi: 10.1093/bib/bbm015 . PMID   17502335.
  34. Stevens, R; Goble, C. A.; Bechhofer, S (2000). "Ontology-based knowledge representation for bioinformatics". Briefings in Bioinformatics. 1 (4): 398–414. doi: 10.1093/bib/1.4.398 . PMID   11465057.
  35. Ciccarese, P; Soiland-Reyes, S; Belhajjame, K; Gray, A. J.; Goble, C; Clark, T (2013). "PAV ontology: Provenance, authoring and versioning". Journal of Biomedical Semantics . 4 (1): 37. arXiv: 1304.7224 . Bibcode:2013arXiv1304.7224C. doi: 10.1186/2041-1480-4-37 . PMC   4177195 . PMID   24267948.
  36. Sansone, S. A.; Rocca-Serra, P.; Field, D.; Maguire, E.; Taylor, C.; Hofmann, O.; Fang, H.; Neumann, S.; Tong, W.; Amaral-Zettler, L.; Begley, K.; Booth, T.; Bougueleret, L.; Burns, G.; Chapman, B.; Clark, T.; Coleman, L. A.; Copeland, J.; Das, S.; De Daruvar, A.; De Matos, P.; Dix, I.; Edmunds, S.; Evelo, C. T.; Forster, M. J.; Gaudet, P.; Gilbert, J.; Goble, C.; Griffin, J. L.; Jacob, D. (2012). "Toward interoperable bioscience data". Nature Genetics. 44 (2): 121–126. doi:10.1038/ng.1054. PMC   3428019 . PMID   22281772.
  37. Williams, A. J.; Harland, L.; Groth, P.; Pettifer, S.; Chichester, C.; Willighagen, E. L.; Evelo, C. T.; Blomberg, N.; Ecker, G.; Goble, C.; Mons, B. (2012). "Open PHACTS: Semantic interoperability for drug discovery" (PDF). Drug Discovery Today . 17 (21–22): 1188–1198. doi: 10.1016/j.drudis.2012.05.016 . PMID   22683805.
  38. Goble, C; Stevens, R; Bechhofer, S (2005). "The semantic web and knowledge grids". Drug Discovery Today: Technologies. 2 (3): 225–33. doi:10.1016/j.ddtec.2005.08.005. PMID   24981940.
  39. Carole Goble publications indexed by the Scopus bibliographic database. (subscription required)
  40. Carole Goble author profile page at the ACM Digital Library OOjs UI icon edit-ltr-progressive.svg
  41. Qiu, J.; Foster, I.; Goble, C. (2014). "Emerging Computational Methods for the Life Sciences Workshop 2012". Concurrency and Computation: Practice and Experience. 26 (6): 1231–1233. doi:10.1002/cpe.3101. S2CID   26141575.
  42. Gaudet, P.; Bairoch, A.; Field, D.; Sansone, S. -A.; Taylor, C.; Attwood, T. K.; Bateman, A.; Blake, J. A.; Bult, C. J.; Cherry, J. M.; Chisholm, R. L.; Cochrane, G.; Cook, C. E.; Eppig, J. T.; Galperin, M. Y.; Gentleman, R.; Goble, C. A.; Gojobori, T.; Hancock, J. M.; Howe, D. G.; Imanishi, T.; Kelso, J.; Landsman, D.; Lewis, S. E.; Karsch Mizrachi, I.; Orchard, S.; Ouellette, B. F. F.; Ranganathan, S.; Richardson, L.; Rocca-Serra, P. (2011). "Towards BioDBcore: A community-defined information specification for biological databases". Database. 2011: baq027. doi:10.1093/database/baq027. PMC   3017395 . PMID   21205783.
  43. Goble, C. A.; Stevens, R.; Ng, G.; Bechhofer, S.; Paton, N. W.; Baker, P. G.; Peim, M.; Brass, A. (2001). "Transparent access to multiple bioinformatics information sources" (PDF). IBM Systems Journal. 40 (2): 532–551. doi:10.1147/sj.402.0532.
  44. "Carole Goble awarded a CBE for services to science". websemanticsjournal.org. Retrieved 27 April 2021.
  45. http://www.cs.manchester.ac.uk/business/spinout/cerebra/ Archived 28 December 2010 at the Wayback Machine Cerebra
  46. Harper, S.; Goble, C.; Stevens, R. (2001). "Prototype mobility tools for visually impaired surfers". Proceedings of the twelfth ACM conference on Hypertext and Hypermedia - HYPERTEXT '01. p. 33. doi:10.1145/504216.504229. ISBN   978-1-58113-420-9. S2CID   331608.
  47. Goble, Carole (26 July 2013). "ISMB/ECCB 2013 Keynote Goble Results may vary: what is reproducible? …". slideshare.net.
  48. http://www.ijcai-07.org/speakers.php Archived 19 February 2012 at the Wayback Machine Keynote speakers at the International Joint Conference on Artificial Intelligence 2007
  49. http://www2006.org/speakers/goble/ Archived 11 April 2018 at the Wayback Machine Carole Goble speaker information from WWW2006
    - Proceedings of the 15th international conference on World Wide Web. ACM. 2006. ISBN   9781595933232.
  50. "No. 60728". The London Gazette (Supplement). 31 December 2013. p. 8.
  51. Anon (2020). "Professor Carole Goble CBE". raeng.org.uk. Royal Academy of Engineering. Archived from the original on 15 June 2020. "Computing is not just about technology – it is actually more about working with and for people"
  52. "Congratulations to Carole Goble on Honorary Doctorate" . Retrieved 3 February 2018.