Conjunctivitis

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Conjunctivitis
Other namesPink eye
An eye with viral conjunctivitis.jpg
An eye with viral conjunctivitis
Specialty Ophthalmology, optometry
Symptoms Reddish eye, scratchiness [1]
DurationViral conjunctivitis: up to two weeks [2]
Causes Viral, bacterial, allergies [3]
Diagnostic method Based on symptoms, microbial culture [1]
Prevention Handwashing [1]
TreatmentBased on underlying cause [3]
Frequency3–6 million per year (US) [1] [3]

Conjunctivitis, also known as pink eye, [4] is inflammation of the outermost layer of the white part of the eye and the inner surface of the eyelid. [5] It makes the eye appear pink or reddish. [1] Pain, burning, scratchiness, or itchiness may occur. [1] The affected eye may have increased tears or be "stuck shut" in the morning. [1] Swelling of the white part of the eye may also occur. [1] Itching is more common in cases due to allergies. [3] Conjunctivitis can affect one or both eyes. [1]

Contents

The most common infectious causes in adults are viral, whereas in children bacterial causes predominate. [6] [3] The viral infection may occur along with other symptoms of a common cold. [1] Both viral and bacterial cases are easily spread between people. [1] Allergies to pollen or animal hair are also a common cause. [3] Diagnosis is often based on signs and symptoms. [1] Occasionally, a sample of the discharge is sent for culture. [1]

Prevention is partly by handwashing. [1] Treatment depends on the underlying cause. [1] In the majority of viral cases, there is no specific treatment. [3] Most cases due to a bacterial infection also resolve without treatment; however, antibiotics can shorten the illness. [1] [3] People who wear contact lenses and those whose infection is caused by gonorrhea or chlamydia should be treated. [3] Allergic cases can be treated with antihistamines or mast cell inhibitor drops. [3]

About 3 to 6 million people get acute conjunctivitis each year in the United States. [1] [3] Typically, people get better in one or two weeks. [1] [3] If visual loss, significant pain, sensitivity to light or signs of herpes occur, or if symptoms do not improve after a week, further diagnosis and treatment may be required. [3] Conjunctivitis in a newborn, known as neonatal conjunctivitis, may also require specific treatment. [1]

Signs and symptoms

Bloodshot eyes Bloodshot eye.jpg
Bloodshot eyes

Red eye, swelling of the conjunctiva, and watering of the eyes are symptoms common to all forms of conjunctivitis. However, the pupils should be normally reactive, and the visual acuity normal. [7]

Conjunctivitis is identified by inflammation of the conjunctiva, manifested by irritation and redness. Examination using a slit lamp (biomicroscope) may improve diagnostic accuracy. Examination of the palpebral conjunctiva, that overlying the inner aspects of the eyelids, is usually more diagnostic than examination of the bulbal conjunctiva, that overlying the sclera.[ citation needed ]

Viral

Viral conjunctivitis Conjunctivitis disease.jpg
Viral conjunctivitis

Approximately 80% of cases of conjunctivitis in adults and less than 20% in children are due to viruses, with 65% to 90% of these cases being attributed to adenoviruses. [8] [6] Viral conjunctivitis is often associated with an infection of the upper respiratory tract, a common cold, or a sore throat. Other associated signs may include pre-auricular lymph node swelling and contact with another person with a red eye. [6] Eye pain may be present if the cornea is also involved. [6] Its symptoms include excessive watering and itching. The discharge in viral conjunctivitis is usually (but not always) watery in nature. [6] The infection usually begins in one eye but may spread easily to the other eye.[ citation needed ]

Viral conjunctivitis manifests as a fine, diffuse pinkness of the conjunctiva which may be mistaken for iritis, but corroborative signs on microscopy, particularly numerous lymphoid follicles on the tarsal conjunctiva, and sometimes a punctate keratitis are seen.[ citation needed ]

Allergic

An eye with allergic conjunctivitis showing conjunctival edema Allergicconjunctivitis.jpg
An eye with allergic conjunctivitis showing conjunctival edema

Allergic conjunctivitis is inflammation of the conjunctiva due to allergy. [9] The specific allergens may differ among patients. Symptoms result from the release of histamine and other active substances by mast cells, and consist of redness (mainly due to vasodilation of the peripheral small blood vessels), swelling of the conjunctiva, itching, and increased production of tears.[ citation needed ]

Bacterial

An eye with bacterial conjunctivitis Swollen eye with conjunctivitis.jpg
An eye with bacterial conjunctivitis

Bacteria are responsible for approximately 70% of conjunctivitis in children and less than 20% of cases in adults. [6] Common bacteria responsible for bacterial conjunctivitis are Staphylococcus including Staph aureus, Streptococcus such as strep pneumoniae, [10] Haemophilus species and Moraxella catarrhalis. [6] Less commonly, Chlamydia spp. and Niesseria species (Neisseria gonorrhoeae and Neisseria meningitidis) may be the cause. [6] [11] Bacterial conjunctivitis usually causes a rapid onset of conjunctival redness, swelling of the eyelid, and a sticky discharge. Typically, symptoms develop first in one eye, but may spread to the other eye within 2–5 days. Conjunctivitis due to common pus-producing bacteria causes marked grittiness or irritation and a stringy, opaque, greyish or yellowish discharge that may cause the lids to stick together, especially after sleep. Severe crusting of the infected eye and the surrounding skin may also occur. The gritty or scratchy feeling is sometimes localized enough that patients may insist that they have a foreign body in the eye.[ citation needed ]

Typical membranous conjunctivitis Membranous conjunctivitis.jpg
Typical membranous conjunctivitis

Bacteria such as Chlamydia trachomatis or Moraxella spp. can cause a nonexudative but persistent conjunctivitis without much redness. Bacterial conjunctivitis may cause the production of membranes or pseudomembranes that cover the conjunctiva. Pseudomembranes consist of a combination of inflammatory cells and exudates and adhere loosely to the conjunctiva, while true membranes are more tightly adherent and cannot be easily peeled away. Cases of bacterial conjunctivitis that involve the production of membranes or pseudomembranes are associated with Neisseria gonorrhoeae , β-hemolytic streptococci, and Corynebacterium diphtheriae . C. diphtheriae causes membrane formation in conjunctiva of unimmunized children. [12]

Chemical

Chemical eye injury may result when an acidic or alkaline substance gets in the eye. [13] Alkali burns are typically worse than acidic burns. [14] Mild burns produce conjunctivitis, while more severe burns may cause the cornea to turn white. [14] Litmus paper may be used to test for chemical causes. [13] When a chemical cause has been confirmed, the eye or eyes should be flushed until the pH is in the range 6–8. [14] Anaesthetic eye drops can be used to decrease the pain. [14]

Irritant or toxic conjunctivitis is primarily marked by redness. If due to a chemical splash, it is often present in only the lower conjunctival sac. With some chemicals, above all with caustic alkalis such as sodium hydroxide, necrosis of the conjunctiva marked by a deceptively white eye due to vascular closure may occur, followed by sloughing off of the dead epithelium. A slit lamp examination is likely to show evidence of anterior uveitis.[ citation needed ]

Biomarkers

Omics technologies have been used to identify biomarkers that inform on the emergence and progression of conjunctivitis. For example, in chronic inflammatory cicatrizing conjunctivitis, active oxylipins, lysophospholipids, fatty acids, and endocannabinoids alterations, from which potential biomarkers linked to inflammatory processes were identified. [15]

Other

An eye with chlamydial conjunctivitis Chlamydial-conjunctivitis.jpg
An eye with chlamydial conjunctivitis

Inclusion conjunctivitis of the newborn is a conjunctivitis that may be caused by the bacterium Chlamydia trachomatis, and may lead to acute, purulent conjunctivitis. [16] However, it is usually self-healing. [16]

Causes

Infective conjunctivitis is most commonly caused by a virus. [3] Bacterial infections, allergies, other irritants, and dryness are also common causes. Both bacterial and viral infections are contagious, passing from person to person or spread through contaminated objects or water. Contact with contaminated fingers is a common cause of conjunctivitis. Bacteria may also reach the conjunctiva from the edges of the eyelids and the surrounding skin, from the nasopharynx, from infected eye drops or contact lenses, from the genitals or the bloodstream. [17] Infection by human adenovirus accounts for 65% to 90% of cases of viral conjunctivitis. [18]

Viral

Adenoviruses are the most common cause of viral conjunctivitis (adenoviral keratoconjunctivitis). [19] Herpetic keratoconjunctivitis, caused by herpes simplex viruses, can be serious and requires treatment with aciclovir. Acute hemorrhagic conjunctivitis is a highly contagious disease caused by one of two enteroviruses, enterovirus 70 and coxsackievirus A24. These were first identified in an outbreak in Ghana in 1969, and have spread worldwide since then, causing several epidemics. [20]

Bacterial

The most common causes of acute bacterial conjunctivitis are Staphylococcus aureus , Streptococcus pneumoniae , and Haemophilus influenzae . [19] [21] Though very rare, hyperacute cases are usually caused by Neisseria gonorrhoeae or Neisseria meningitidis . Chronic cases of bacterial conjunctivitis are those lasting longer than 3 weeks, and are typically caused by S. aureus, Moraxella lacunata , or Gram-negative enteric flora.[ citation needed ]

Allergic

Conjunctivitis may also be caused by allergens such as pollen, perfumes, cosmetics, smoke, [22] [ unreliable medical source? ] dust mites, Balsam of Peru, [23] or eye drops. [24] The most frequent cause of conjunctivitis is allergic conjunctivitis and it affects 15% to 40% of the population. [25] Allergic conjunctivitis accounts for 15% of eye related primary care consultations; most including seasonal exposures in the spring and summer or perpetual conditions. [26]

Other

Diagnosis

The procedure of conjunctival swabs Procedure of conjunctival swabs.jpg
The procedure of conjunctival swabs

Cultures are not often taken or needed as most cases resolve either with time or typical antibiotics. If bacterial conjunctivitis is suspected, but no response to topical antibiotics is seen, swabs for bacterial culture should be taken and tested. Viral culture may be appropriate in epidemic case clusters. [29]

A patch test is used to identify the causative allergen in allergic conjunctivitis. [30]

Although conjunctival scrapes for cytology can be useful in detecting chlamydial and fungal infections, allergies, and dysplasia, they are rarely done because of the cost and the general dearth of laboratory staff experienced in handling ocular specimens. Conjunctival incisional biopsy is occasionally done when granulomatous diseases (e.g., sarcoidosis) [31] or dysplasia are suspected. [32]

Classification

Conjunctivitis may be classified either by cause or by extent of the inflamed area.[ citation needed ]

Causes

  • Allergy
  • Bacteria
  • Viruses
  • Chemicals
  • Autoimmune

Neonatal conjunctivitis is often grouped separately from bacterial conjunctivitis because it is caused by different bacteria than the more common cases of bacterial conjunctivitis.[ citation needed ]

By extent of involvement

Blepharoconjunctivitis is the dual combination of conjunctivitis with blepharitis (inflammation of the eyelids).[ citation needed ]

Keratoconjunctivitis is the combination of conjunctivitis and keratitis (corneal inflammation).[ citation needed ]

Blepharokeratoconjunctivitis is the combination of conjunctivitis with blepharitis and keratitis. It is clinically defined by changes of the lid margin, meibomian gland dysfunction, redness of the eye, conjunctival chemosis and inflammation of the cornea. [33]

Differential diagnosis

Some more serious conditions can present with a red eye, such as infectious keratitis, angle-closure glaucoma, or iritis. These conditions require the urgent attention of an ophthalmologist. Signs of such conditions include decreased vision, significantly increased sensitivity to light, inability to keep the eye open, a pupil that does not respond to light, or a severe headache with nausea. [34] Fluctuating blurring is common, due to tearing and mucoid discharge. Mild photophobia is common. However, if any of these symptoms is prominent, considering other diseases such as glaucoma, uveitis, keratitis, and even meningitis or carotico-cavernous fistula is important.[ citation needed ]

A more comprehensive differential diagnosis for the red or painful eye includes: [34]

Prevention

The most effective prevention is good hygiene, especially avoiding rubbing the eyes with infected hands. Vaccination against some of the causative pathogens such as Haemophilus influenzae, pneumococcus, and Neisseria meningitidis is also effective. [35]

Povidone-iodine eye solution has been found to prevent neonatal conjunctivitis. [36] It is becoming more commonly used globally because of its low cost. [36]

Management

Conjunctivitis resolves in 65% of cases without treatment, within 2–5 days. The prescription of antibiotics is not necessary in most cases. [37]

Viral

Viral conjunctivitis usually resolves on its own and does not require any specific treatment. [3] Antihistamines (e.g., diphenhydramine) or mast cell stabilizers (e.g., cromolyn) may be used to help with the symptoms. [3] Povidone-iodine has been suggested as a treatment, but as of 2008, evidence to support it was poor. [38]

Allergic

For allergic conjunctivitis, cool water poured over the face with the head inclined downward constricts capillaries, and artificial tears sometimes relieve discomfort in mild cases. In more severe cases, nonsteroidal anti-inflammatory medications and antihistamines may be prescribed. Persistent allergic conjunctivitis may also require topical steroid drops. [39]

Bacterial

Bacterial conjunctivitis usually resolves without treatment. [3] Topical antibiotics may be needed only if no improvement is observed after 3 days. [40] No serious effects were noted either with or without treatment. [41] Because antibiotics do speed healing in bacterial conjunctivitis, their use may be considered. [41] Antibiotics are also recommended for those who wear contact lenses, are immunocompromised, have disease which is thought to be due to chlamydia or gonorrhea, have a fair bit of pain, or have copious discharge. [3] Gonorrheal or chlamydial infections require both oral and topical antibiotics. [3]

The choice of antibiotic varies based on the strain or suspected strain of bacteria causing the infection. Fluoroquinolones, sodium sulfacetamide, or trimethoprim/polymyxin may be used, typically for 7–10 days. [19] Cases of meningococcal conjunctivitis can also be treated with systemic penicillin, as long as the strain is sensitive to penicillin.[ citation needed ]

When investigated as a treatment, povidone-iodine ophthalmic solution has also been observed to have some effectiveness against bacterial and chlamydial conjunctivitis, with a possible role suggested in locations where topical antibiotics are unavailable or costly. [42]

Chemical

Conjunctivitis due to chemicals is treated via irrigation with Ringer's lactate or saline solution. Chemical injuries, particularly alkali burns, are medical emergencies, as they can lead to severe scarring and intraocular damage. People with chemically induced conjunctivitis should not touch their eyes to avoid spreading the chemical. [43]


Epidemiology

Conjunctivitis is the most common eye disease. [44] Rates of disease is related to the underlying cause which varies by the age as well as the time of year. Acute conjunctivitis is most frequently found in infants, school-age children and the elderly. [17] The most common cause of infectious conjunctivitis is viral conjunctivitis. [25]

It is estimated that acute conjunctivitis affects 6 million people annually in the United States. [3]

Some seasonal trends have been observed for the occurrence of different forms of conjunctivitis. In the northern hemisphere, the occurrence of bacterial conjunctivitis peaks from December to April, viral conjunctivitis peaks in the summer months and allergic conjunctivitis is more prevalent throughout the spring and summer. [17]

History

An adenovirus was first isolated by Rowe et al. in 1953. Two years later, Jawetz et al. published on epidemic keratoconjunctivitis. [45] : 437  "Madras eye" is a colloquial term that has been used in India for the disease.

Outbreak in Pakistan

In September 2023, a significant outbreak of conjunctivitis occurred in Pakistan. The outbreak began in Karachi and quickly spread to Lahore, Rawalpindi, and Islamabad. By the end of the month, over 86,133 cases had been reported in Punjab alone. The rapid spread of the disease led to the temporary closure of schools in the region. This event marked one of the largest outbreaks of Pink Eye in the country's recent history. [46] [47] [48] [49]

Society and culture

Conjunctivitis imposes economic and social burdens. The cost of treating bacterial conjunctivitis in the United States was estimated to be $377 million to $857 million per year. [3] Approximately 1% of all primary care office visits in the United States are related to conjunctivitis. Approximately 70% of all people with acute conjunctivitis present to primary care and urgent care. [3]

See also

Related Research Articles

<span class="mw-page-title-main">Keratitis</span> Medical condition

Keratitis is a condition in which the eye's cornea, the clear dome on the front surface of the eye, becomes inflamed. The condition is often marked by moderate to intense pain and usually involves any of the following symptoms: pain, impaired eyesight, photophobia, red eye and a 'gritty' sensation. Diagnosis of infectious keratitis is usually made clinically based on the signs and symptoms as well as eye examination, but corneal scrapings may be obtained and evaluated using microbiological culture or other testing to identify the causative pathogen.

<span class="mw-page-title-main">Laryngitis</span> Medical condition

Laryngitis is inflammation of the larynx. Symptoms often include a hoarse voice and may include fever, cough, pain in the front of the neck, and trouble swallowing. Typically, these last under two weeks.

<span class="mw-page-title-main">Prednisolone</span> Corticosteroid medication

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<span class="mw-page-title-main">Blepharitis</span> Medical condition of the eyelid

Blepharitis, sometimes known as granulated eyelids, is one of the most common ocular conditions characterized by inflammation, scaling, reddening, and crusting of the eyelid. This condition may also cause swelling, burning, itching, or a grainy sensation when introducing foreign objects or substances to the eye. Although blepharitis by itself is not sight-threatening, it can lead to permanent alterations of the eyelid margin. The primary cause is bacteria and inflammation from congested meibomian oil glands at the base of each eyelash. Other conditions may give rise to blepharitis, whether they be infectious or noninfectious, including, but not limited to, bacterial infections or allergies.

<span class="mw-page-title-main">Red eye (medicine)</span> Eye that appears red due to illness or injury

A red eye is an eye that appears red due to illness or injury. It is usually injection and prominence of the superficial blood vessels of the conjunctiva, which may be caused by disorders of these or adjacent structures. Conjunctivitis and subconjunctival hemorrhage are two of the less serious but more common causes.

<span class="mw-page-title-main">Allergic conjunctivitis</span> Medical condition

Allergic conjunctivitis (AC) is inflammation of the conjunctiva due to allergy. Although allergens differ among patients, the most common cause is hay fever. Symptoms consist of redness, edema (swelling) of the conjunctiva, itching, and increased lacrimation. If this is combined with rhinitis, the condition is termed allergic rhinoconjunctivitis (ARC).

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Brazilian purpuric fever (BPF) is an illness of children caused by the bacterium Haemophilus influenzae biogroup aegyptius which is ultimately fatal due to sepsis. BPF was first recognized in the São Paulo state of Brazil in 1984. At this time, young children between the ages of 3 months and 10 years were contracting a strange illness which was characterized by high fever and purpuric lesions on the body. These cases were all fatal, and originally thought to be due to meningitis. It was not until the autopsies were conducted that the cause of these deaths was confirmed to be infection by H. influenzae aegyptius. Although BPF was thought to be confined to Brazil, other cases occurred in Australia and the United States during 1984–1990.

<span class="mw-page-title-main">Phlyctenular keratoconjunctivitis</span> Medical condition

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<span class="mw-page-title-main">Neonatal conjunctivitis</span> Medical condition

Neonatal conjunctivitis is a form of conjunctivitis which affects newborn babies following birth. It is typically due to neonatal bacterial infection, although it can also be non-infectious. Infectious neonatal conjunctivitis is typically contracted during vaginal delivery from exposure to bacteria from the birth canal, most commonly Neisseria gonorrhoeae or Chlamydia trachomatis.

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<span class="mw-page-title-main">Vernal keratoconjunctivitis</span> Medical condition

Vernal keratoconjunctivitis is a recurrent, bilateral, and self-limiting type of conjunctivitis having a periodic seasonal incidence.

<span class="mw-page-title-main">Feline viral rhinotracheitis</span> Infectious disease of cats

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<span class="mw-page-title-main">Endophthalmitis</span> Medical condition

Endophthalmitis, or endophthalmia, is inflammation of the interior cavity of the eye, usually caused by an infection. It is a possible complication of all intraocular surgeries, particularly cataract surgery, and can result in loss of vision or loss of the eye itself. Infection can be caused by bacteria or fungi, and is classified as exogenous, or endogenous. Other non-infectious causes include toxins, allergic reactions, and retained intraocular foreign bodies. Intravitreal injections are a rare cause, with an incidence rate usually less than 0.05%.

Infectious bovine keratoconjunctivitis (IBK), also known as pinkeye, New Forest eye or blight, is a veterinary infection of cattle caused by Moraxella bovis, a Gram-negative, β-haemolytic, aerobic, rod-shaped bacterium. It is spread by direct contact or by flies serving as vectors. It is the most common ocular disease of cattle. IBK is similar to human pink eye and causes severe infection of the conjunctiva, edema, corneal opacity, and ulceration. This disease is highly contagious and occurs worldwide. Younger animals are more susceptible, but recovery with minimal damage is usual, if they are treated early.

<span class="mw-page-title-main">Corneal ulcer</span> Medical condition of the eye

Corneal ulcer, also called keratitis, is an inflammatory or, more seriously, infective condition of the cornea involving disruption of its epithelial layer with involvement of the corneal stroma. It is a common condition in humans particularly in the tropics and in farming. In developing countries, children afflicted by vitamin A deficiency are at high risk for corneal ulcer and may become blind in both eyes persisting throughout life. In ophthalmology, a corneal ulcer usually refers to having an infection, while the term corneal abrasion refers more to a scratch injury.

<span class="mw-page-title-main">Acute haemorrhagic conjunctivitis in Ghana</span> Aspect of public health in Ghana

Acute Haemmorrhagic Conjunctivitis is the inflammation of the conjunctiva of sudden onset. It presents as a reddening of the eye due to the infection of the conjunctiva. The conjunctiva is the thin transparent tissue that covers the eye from the Corneal limbus to the lid margin. Many conditions can lead to the inflammation of the conjunctiva. They include allergies, bacterial infection, viral infection etc. A common form of the condition that occurs every rainy season is the seasonal conjunctivitis popularly referred to as "Apollo" by West Africans because the reports of its first epidemic in Accra coincided with the Apollo 11 Moon landing. Every year prior to the rainy season in the country, various health warnings are given to remind citizens of the condition.

<span class="mw-page-title-main">Herpes simplex keratitis</span> Medical condition

Herpetic simplex keratitis is a form of keratitis caused by recurrent herpes simplex virus (HSV) infection in the cornea.

<span class="mw-page-title-main">Intravitreal injection</span> Method of administration of drugs into the eye by injection with a fine needle

Intravitreal injection is the method of administration of drugs into the eye by injection with a fine needle. The medication will be directly applied into the vitreous humor. It is used to treat various eye diseases, such as age-related macular degeneration (AMD), diabetic retinopathy, and infections inside the eye such as endophthalmitis. As compared to topical administration, this method is beneficial for a more localized delivery of medications to the targeted site, as the needle can directly pass through the anatomical eye barrier and dynamic barrier. It could also minimize adverse drug effects on other body tissues via the systemic circulation, which could be a possible risk for intravenous injection of medications. Although there are risks of infections or other complications, with suitable precautions throughout the injection process, chances for these complications could be lowered.

Exposure keratopathy is medical condition affecting the cornea of eyes. It can lead to corneal ulceration and permanent loss of vision due to corneal opacity.

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