Stephen Marc Breedlove (born 1954) [1] [2] [ self-published source? ] is the Barnett Rosenberg professor of Neuroscience at Michigan State University in East Lansing, Michigan. [3] He was born and raised in the Ozarks of southwestern Missouri. [2] After graduating from Central High School (Springfield, Missouri) in 1972, [4] he earned a bachelor's degree in Psychology from Yale University in 1976, [2] and a Ph.D. in psychology from UCLA in 1982. [2] He was a professor of psychology at the University of California, Berkeley from 1982 to 2003, [2] moving to Michigan State in 2001. [2] He works in the fields of Behavioral Neuroscience and Neuroendocrinology. He is a member of the Society for Neuroscience [5] and the Society for Behavioral Neuroendocrinology, [6] and a fellow of the Association for Psychological Science (APS) [7] and the Biological Sciences section of the American Association for the Advancement of Science (AAAS). [8]
In numerous papers, Breedlove has demonstrated that steroid hormones and sexual behavior affect the developing and adult spinal cord and brain. He also reported that the average digit ratio of lesbians is more masculine than that of straight women, [9] a finding that has been replicated in his [10] and many other labs [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] and which indicates that lesbians, on average, are exposed to more prenatal testosterone than are straight women. This finding joins many others that biological influences, such as prenatal testosterone and fraternal birth order, [22] act before birth to affect the later unfolding of human sexual orientation, which is the theme for the documentary project Whom You Love.
He is sole author of two textbooks Principles of Psychology and Foundations of Neural Development and has co-authored textbooks in Biological Psychology and Behavioral Neuroendocrinology. [23] [24] [25] [26]
Breedlove, along with other neuroscientists, researched PTSD being connected to erectile dysfunction. This erectile dysfunction is usually treated by psychotherapy. Breedlove helped to find the receptor that is affected by the PTSD. This was found through a series of stress tests on rats. The receptor is called the gastrin-releasing peptide (GRP) receptor. This receptor is stress-vulnerable and should be targeted in treatment. [27]
He also researched how GRP in the lumbar spinal cord could be stimulated for the purpose of curing erectile dysfunction. It was found that the female rats and the male rats with erectile dysfunction had the same amount of GRP. Once the GRP was stimulated in the male rats, androgen receptors worked, and erectile dysfunction was cured. During the experiment, simple erections, dorsal flips of the penis and cup-like flaring erections of the distal glans were measured in the rats before and after probe stimulation. [28]
Breedlove examined the sex differences in animals to gain an understanding of the sex differences in humans. It was found in rats that the males had more cell numbers in the spinal nucleus of the bulbocavernosus (SNB) than the female rats. These motor neurons appear in both male and female rats, but fade with age in the female rats. Testosterone was also found as the key hormone that is responsible for the differences between males and females. [29]
Breedlove researched the sexual preferences of homosexual men. Using homosexual and heterosexual male participants, it was found that the two groups did not vary according to mating desires. Even though homosexual males cannot reproduce, they, like the heterosexual males, prefer to be with a younger partner. This concludes that both groups' partner references were independent of the evolutionary need for reproduction. [30]
Erectile dysfunction (ED), also called impotence, is the type of sexual dysfunction in which the penis fails to become or stay erect during sexual activity. It is the most common sexual problem in men. Through its connection to self-image and to problems in sexual relationships, erectile dysfunction can cause psychological harm.
Sexual orientation is an enduring pattern of romantic or sexual attraction to persons of the opposite sex or gender, the same sex or gender, or to both sexes or more than one gender. These attractions are generally subsumed under heterosexuality, homosexuality, and bisexuality, while asexuality is sometimes identified as the fourth category.
Testosterone is the primary sex hormone and anabolic steroid in males. In humans, testosterone plays a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair, and psychological characteristics in males such as increased aggression, sex drive, the inclination to impress partners and other courting behaviors. In addition, testosterone in both sexes is involved in health and well-being, where it has a significant effect on overall mood, cognition, social and sexual behaviour, metabolism and energy output, the cardiovascular system, and in the prevention of osteoporosis. Insufficient levels of testosterone in men may lead to abnormalities including frailty, accumulation of adipose fat tissue within the body, anxiety and depression, sexual performance issues, and bone loss.
The relationship between biology and sexual orientation is a subject of research. While scientists do not know the exact cause of sexual orientation, they theorize that it is caused by a complex interplay of genetic, hormonal, and environmental influences. Hypotheses for the impact of the post-natal social environment on sexual orientation, however, are weak, especially for males.
The hypothalamus is a part of the brain that contains a number of small nuclei with a variety of functions. One of the most important functions is to link the nervous system to the endocrine system via the pituitary gland. The hypothalamus is located below the thalamus and is part of the limbic system. In the terminology of neuroanatomy, it forms the ventral part of the diencephalon. All vertebrate brains contain a hypothalamus. In humans, it is the size of an almond.
The digit ratio is the ratio of the lengths of different digits or fingers on a hand, the study of which has been considered pseudoscience. The 2D:4D ratio is the most studied digit ratio and is calculated by dividing the length of the index finger of a given hand by the length of the ring finger of the same hand. Although studies have claimed to show a correlation between the 2D:4D digit ratio and various physical and behavioral traits, these studies have drawn criticism for irreproducible or contradictory findings, exaggerated claims of usefulness, and lack of high quality research protocols.
Oxytocin is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. Present in animals since early stages of evolution, in humans it plays roles in behavior that include social bonding, reproduction, childbirth, and the period after childbirth. Oxytocin is released into the bloodstream as a hormone in response to sexual activity and during labour. It is also available in pharmaceutical form. In either form, oxytocin stimulates uterine contractions to speed up the process of childbirth. In its natural form, it also plays a role in bonding with the baby and milk production. Production and secretion of oxytocin is controlled by a positive feedback mechanism, where its initial release stimulates production and release of further oxytocin. For example, when oxytocin is released during a contraction of the uterus at the start of childbirth, this stimulates production and release of more oxytocin and an increase in the intensity and frequency of contractions. This process compounds in intensity and frequency and continues until the triggering activity ceases. A similar process takes place during lactation and during sexual activity.
An androgen is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. This includes the embryological development of the primary male sex organs, and the development of male secondary sex characteristics at puberty. Androgens are synthesized in the testes, the ovaries, and the adrenal glands.
Sexual dysfunction is difficulty experienced by an individual or partners during any stage of normal sexual activity, including physical pleasure, desire, preference, arousal, or orgasm. The World Health Organization defines sexual dysfunction as a "person's inability to participate in a sexual relationship as they would wish". This definition is broad and is subject to many interpretations. A diagnosis of sexual dysfunction under the DSM-5 requires a person to feel extreme distress and interpersonal strain for a minimum of six months. Sexual dysfunction can have a profound impact on an individual's perceived quality of sexual life. The term sexual disorder may not only refer to physical sexual dysfunction, but to paraphilias as well; this is sometimes termed disorder of sexual preference.
Fraternal birth order has been correlated with male sexual orientation, with a significant volume of research finding that the more older brothers a male has from the same mother, the greater the probability he will have a homosexual orientation. Ray Blanchard and Anthony Bogaert first identified the association in the 1990s and named it the fraternal birth order effect. Scientists have attributed the effect to a prenatal biological mechanism, since the association is only present in men with older biological brothers, and not present among men with older step-brothers and adoptive brothers. The mechanism is thought to be a maternal immune response to male fetuses, whereby antibodies neutralize male Y-proteins thought to play a role in sexual differentiation during development. This would leave some regions of the brain associated with sexual orientation in the 'female typical' arrangement – or attracted to men. Biochemical evidence for this hypothesis was identified in 2017, finding mothers with a gay son, particularly those with older brothers, had heightened levels of antibodies to the NLGN4Y Y-protein than mothers with heterosexual sons.
The ventromedial nucleus of the hypothalamus is a nucleus of the hypothalamus. In 2007, Kurrasch et al. found that the ventromedial hypothalamus is a distinct morphological nucleus involved in terminating hunger, fear, thermoregulation, and sexual activity. This nuclear region is involved in the recognition of the feeling of fullness.
A relationship between handedness and sexual orientation has been suggested by a number of researchers, who report that heterosexual individuals are somewhat more likely to be right-handed than are homosexual individuals.
The relationship between the environment and sexual orientation is a subject of research. In the study of sexual orientation, some researchers distinguish environmental influences from hormonal influences, while other researchers include biological influences such as prenatal hormones as part of environmental influences.
Sexual orientation is an enduring pattern of romantic or sexual attraction to persons of the opposite sex or gender, the same sex or gender, or to both sexes or more than one gender, or none of the aforementioned at all. The ultimate causes and mechanisms of sexual orientation development in humans remain unclear and many theories are speculative and controversial. However, advances in neuroscience explain and illustrate characteristics linked to sexual orientation. Studies have explored structural neural-correlates, functional and/or cognitive relationships, and developmental theories relating to sexual orientation in humans.
Sexual fluidity is one or more changes in sexuality or sexual identity. Sexual orientation is stable and unchanging for the vast majority of people, but some research indicates that some people may experience change in their sexual orientation, and this is slightly more likely for women than for men. There is no scientific evidence that sexual orientation can be changed through psychotherapy. Sexual identity can change throughout an individual's life, and may or may not align with biological sex, sexual behavior or actual sexual orientation.
The hormonal theory of sexuality holds that, just as exposure to certain hormones plays a role in fetal sex differentiation, such exposure also influences the sexual orientation that emerges later in the individual. Prenatal hormones may be seen as the primary determinant of adult sexual orientation, or a co-factor with genes, biological factors and/or environmental and social conditions.
Sexual motivation is influenced by hormones such as testosterone, estrogen, progesterone, oxytocin, and vasopressin. In most mammalian species, sex hormones control the ability and motivation to engage in sexual behaviours.
Behavioral endocrinology is a branch of endocrinology that studies the Neuroendocrine system and its effects on behavior. Behavioral endocrinology studies the biological mechanisms that produce behaviors, this gives insight into the evolutionary past. The field has roots in ethology, endocrinology and psychology.
Josephine Ball was an American comparative psychologist, endocrinologist, and clinical psychologist best known as an early pioneer in the study of reproductive behavior and neuroendocrinology (1920s-1940s). She later worked as a clinical psychologist in the New York State health system and at the Veteran's Administration Hospital in Perry Point, Maryland.
Staci Bilbo is an American neuroimmunologist and The Haley Family Professor of Psychology and Neuroscience at Duke University. Bilbo also holds a position as a research affiliate at Massachusetts General Hospital overseeing research within the Lurie Center for Autism. As the principal investigator of the Bilbo Lab, Bilbo investigates how environmental challenges during the perinatal period impact the immune system and further influence brain development, cognition, and affective behaviors later in life..