Anne-Maree Pearse

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Anne-Maree Pearse
Alma materUniversity of Sydney

University of Tasmania

Known forDevil facial tumour disease
Awards2011 Australian Museum Eureka Prize

2012 Prince Hitachi Prize

Scientific career
FieldsCytogenetics

Anne-Maree Pearse is an Australian cytogeneticist who is credited with the theory that some cancer cells can be transmissible between individuals. This is known as the allograft theory. Her work has focussed on devil facial tumour disease (DFTD), a contagious cancer that affects Tasmanian devils. For this she has won multiple awards, including the 2012 Prince Hitachi Prize for Comparative Oncology.

Contents

Education

Pearse graduated from the University of Sydney in 1972 before starting an MSc at the University of Tasmania in 1976. [1] During her Masters she worked on the flea, Uropsylla tasmanica , which is a flea that infects quolls and Tasmanian devils. [1] She was unable to complete her PhD due to symptoms of progressive and severe degenerative disc disease. [2]

Career

Pearse worked in the Cytogenetics Laboratory at the Royal Hobart Hospital, Tasmania for seventeen years where she worked on human leukemia but also continued studying quolls. [1] [3] [4] During this period she published work on cancer in quolls. [5] She initially retired from scientific work, establishing a flower farm, before returning to science to work on DFTD. [6] She joined the Save the Tasmanian Devil program at the Department of Primary Industries, Parks, Water and Environment, Tasmanian Government, in 2004 after hearing about the disease on the radio. [1] [4]

Tumours protrude from the face of a Tasmanian devil Tasmanian Devil Facial Tumour Disease.png
Tumours protrude from the face of a Tasmanian devil

In 2006, Pearse and her colleague Swift published a paper on their findings on DFTD in Nature . [7] In their report they studied tumours from eleven Tasmanian devils. They observed that the tumours had major chromosomal abnormalities and these abnormalities were the same between individual animals. This led them to conclude that the tumour cells in different animals were of the same clonal origin. As a result, they proposed the hypothesis that "the disease is transmitted by allograft, whereby an infectious cell line is passed directly between the animals through bites they inflict on one another.". [7]

Since then, other scientists have added further evidence to the Allograft Theory of DFTD whilst Pearse has continued to uncover new information on the disease. [8] In particular, she has investigated how the disease mutates in Tasmanian Devil populations. [9] The conclusion of this research is "that DFTD should not be treated as a static entity, but rather as an evolving parasite with epigenetic plasticity". [10]

These findings have implications in humans in terms of donor-derived malignancy in organ transplantation and transmission of a malignancy between a mother and a fetus or between twin fetuses. [2]

Awards and honours

Related Research Articles

<span class="mw-page-title-main">Tasmanian devil</span> Australian carnivorous marsupial

The Tasmanian devil is a carnivorous marsupial of the family Dasyuridae. It was formerly present across mainland Australia, but became extinct there around 3,500 years ago. The size of a small dog, the Tasmanian devil became the largest carnivorous marsupial in the world following the extinction of the thylacine in 1936. It is related to quolls, and distantly related to the thylacine. It is characterised by its stocky and muscular build, black fur, pungent odour, extremely loud and disturbing screech, keen sense of smell, and ferocity when feeding. The Tasmanian devil's large head and neck allow it to generate among the strongest bites per unit body mass of any extant predatory land mammal. It hunts prey and scavenges on carrion.

<span class="mw-page-title-main">Freycinet National Park</span> Protected area in Tasmania, Australia

Freycinet National Park is a national park on the east coast of Tasmania, Australia, 125 kilometres (78 mi) northeast of Hobart. It occupies a large part of the Freycinet Peninsula, named after French navigator Louis de Freycinet, and Schouten Island. Founded in 1916, it is Tasmania's oldest park, along with Mount Field National Park. Bordering the national park is the small settlement of Coles Bay, and the largest nearby town is Swansea. Freycinet contains part of the rugged Tasmanian coastline and includes the secluded Wineglass Bay. Features of the park include its red and pink granite formations and a series of jagged granite peaks in a line, called "The Hazards".

<span class="mw-page-title-main">Tiger quoll</span> Carnivorous marsupial native to Australia

The tiger quoll, also known as the spotted-tail quoll, the spotted quoll, the spotted-tail dasyure, native cat or the tiger cat, is a carnivorous marsupial of the quoll genus Dasyurus native to Australia. With males and females weighing around 3.5 and 1.8 kg, respectively, it is the world's second-largest extant carnivorous marsupial, behind the Tasmanian devil. Two subspecies are recognised; the nominate is found in wet forests of southeastern Australia and Tasmania, and a northern subspecies, D. m. gracilis, is found in a small area of northern Queensland and is endangered.

<span class="mw-page-title-main">Quoll</span> Genus of marsupial mammals

Quolls are carnivorous marsupials native to Australia and New Guinea. They are primarily nocturnal and spend most of the day in a den. Of the six species of quoll, four are found in Australia and two in New Guinea. Another two species are known from fossil remains in Pliocene and Pleistocene deposits in Queensland. Genetic evidence indicates that quolls evolved around 15 million years ago in the Miocene, and that the ancestors of the six species had all diverged by around four million years ago. The six species vary in weight and size, from 300 g (11 oz) to 7 kg (15 lb). They have brown or black fur and pink noses. They are largely solitary, but come together for a few social interactions such as mating which occurs during the winter season. A female gives birth to up to 30 pups, but the number that can be raised to adulthood is limited by the number of teats (6–7). They have a life span of 1–5 years.

<span class="mw-page-title-main">Devil facial tumour disease</span> Cancer affecting Tasmanian devils

Devil facial tumour disease (DFTD) is an aggressive non-viral clonally transmissible cancer which affects Tasmanian devils, a marsupial native to the Australian island of Tasmania. The cancer manifests itself as lumps of soft and ulcerating tissue around the mouth, which may invade surrounding organs and metastasise to other parts of the body. Severe genetic abnormalities exist in cancer cells - for example, DFT2 cells are tetraploid, containing twice as much genetic material as normal cells. DFTD is most often spread by bites, when teeth come into contact with cancer cells; less important pathways of transmission are ingesting of infected carcasses and sharing of food. Adult Tasmanian devils who are otherwise the fittest are most susceptible to the disease.

<span class="mw-page-title-main">Canine transmissible venereal tumor</span> Histiocytic tumor of the external genitalia of the dog and other canines

A canine transmissible venereal tumor (CTVT), also known as a transmissible venereal tumor (TVT), canine transmissible venereal sarcoma (CTVS), sticker tumor and infectious sarcoma, is a histiocytic tumor of the external genitalia of the dog and other canines, and is transmitted from animal to animal during mating. It is one of only three known transmissible cancers in mammals; the others are devil facial tumor disease, a cancer which occurs in Tasmanian devils, and contagious reticulum cell sarcoma of the Syrian hamster.

<span class="mw-page-title-main">Eastern quoll</span> Species of marsupial

The eastern quoll is a medium-sized carnivorous marsupial (dasyurid), and one of six extant species of quolls. Endemic to Australia, they occur on the island state of Tasmania, but were considered extinct on the mainland after 1963. The species has been reintroduced to fox-proof fenced sanctuaries Victoria in 2003 and to the Australian Capital Territory in 2016.

<span class="mw-page-title-main">Neuroendocrine tumor</span> Medical condition

Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. They most commonly occur in the intestine, where they are often called carcinoid tumors, but they are also found in the pancreas, lung, and the rest of the body.

A transmissible cancer is a cancer cell or cluster of cancer cells that can be transferred between individuals without the involvement of an infectious agent, such as an oncovirus. The evolution of transmissible cancer has occurred naturally in other animal species, but human cancer transmission is rare.

<span class="mw-page-title-main">Salivary gland tumour</span> Medical condition

Salivary gland tumours, also known as mucous gland adenomas or neoplasms, are tumours that form in the tissues of salivary glands. The salivary glands are classified as major or minor. The major salivary glands consist of the parotid, submandibular, and sublingual glands. The minor salivary glands consist of 800 to 1000 small mucus-secreting glands located throughout the lining of the oral cavity. Patients with these types of tumours may be asymptomatic.

<span class="mw-page-title-main">Tasmania Zoo</span> Zoo in Launceston, Tasmania, Australia

Tasmania Zoo is a zoo located in Launceston, in the Australian state of Tasmania. Situated on 900 acres (360 ha) of old growth native bushland, it is home to the state's largest collection of native and exotic animals. Tasmania Zoo is a fully accredited member of the Zoo and Aquarium Association, working closely with all Australasian zoos, and are involved in various species management programs.

<span class="mw-page-title-main">Oncology</span> Branch of medicine dealing with, or specializing in, cancer

Oncology is a branch of medicine that deals with the study, treatment, diagnosis and prevention of cancer. A medical professional who practices oncology is an oncologist. The name's etymological origin is the Greek word ὄγκος (ónkos), meaning "tumor", "volume" or "mass". Oncology is concerned with:

<span class="mw-page-title-main">History of cancer</span> Development of oncology and its role

The history of cancer describes the development of the field of oncology and its role in the history of medicine.

Elizabeth Murchison is a British-Australian geneticist, Professor of Comparative Oncology and Genetics at the University of Cambridge, UK. The ongoing research of her group focuses on the known existing clonally transmissible cancers arising in mammals. These are cancers that can be passed on between individuals by the transfer of living cancer cells that somehow manage to evade the immune system of their hosts.

<span class="mw-page-title-main">Katherine Belov</span> Australian geneticist

Katherine Belov is an Australian geneticist, professor of comparative genomics in the School of Life and Environmental Sciences and Pro Vice Chancellor of Global Engagement at the University of Sydney. She is head of the Australasian Wildlife Genomics Group and research expert in the area of comparative genomics and immunogenetics, including Tasmanian devils and koalas, two iconic Australian species that are threatened by disease processes. Throughout her career, she has disproved the idea that marsupial immune system is primitive, characterized the South American gray short-tailed opossum's immune genes, participated in the Platypus Genome Project, led research identifying the properties of platypus venom, and identified the cause of the spread of the Tasmanian devil's contagious cancer.

<span class="mw-page-title-main">Caroline Dive</span> Professor of Cancer Pharmacology

Caroline Dive is a British cancer research scientist. Dive is Professor of Cancer Pharmacology at the University of Manchester, Deputy Director of the Cancer Research UK (CRUK) Manchester Institute, Director of the CRUK Manchester Institute Cancer Biomarker Centre and co-director of the CRUK Lung Cancer Centre of Excellence. She is the current President of The European Association for Cancer Research (EACR).

Comparative oncology integrates the study of oncology in non-human animals into more general studies of cancer biology and therapy. The field encompasses naturally seen cancers in veterinary patients and the extremely low rates of cancers seen in large mammals such as elephants and whales.

Contagious reticulum cell sarcoma is a reticulum-cell sarcoma found in Syrian hamsters that can be transmitted from one hamster to another. It was first described in 1945.

Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, Gorbunova identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat.

Lynn Corcoran is an American–Australian immunologist who is Professor of Immunology at the Walter and Eliza Hall Institute. Her research considers cancer, parasitology and immunology, with a focus on B cells biology. She was inducted into the Victorian government's Honour Roll in 2013.

References

  1. 1 2 3 4 5 "The Awardee of the 2012 Prince Hitachi Prize for Comparative Oncology". jfcr.or.jp. Retrieved 23 March 2019.
  2. 1 2 "The Prince Hitachi Prize for Comparative Oncology | 2012Awardee". www.jfcr.or.jp. Retrieved 28 September 2020.
  3. Melrose, W. D.; Pearse, A. M.; Bell, P. A.; Jupe, D. M.; Baikie, M. J.; Twin, J. E.; Bryant, S. L. (1990). "Haematology of the Australian eastern quoll, Dasyurus viverrinus--II. Red cell enzymes and metabolic intermediates". Comparative Biochemistry and Physiology. B, Comparative Biochemistry. 97 (1): 47–48. doi:10.1016/0305-0491(90)90175-S. ISSN   0305-0491. PMID   2147643.
  4. 1 2 Julie Rehmeyer (31 March 2014). "Fatal Cancer Threatens Tasmanian Devil Population". Discover Magazine. ISSN   0274-7529.
  5. Twin, J. E.; Pearse, A. M. (1986). "A malignant mixed salivary tumour and a mammary carcinoma in a young wild eastern spotted native cat Dasyurus viverrinus (Marsupialia)". Journal of Comparative Pathology. 96 (3): 301–306. doi:10.1016/0021-9975(86)90050-2. ISSN   0021-9975. PMID   3013953.
  6. Quammen, David (2008). "Contagious Cancer". Harper's Magazine. ISSN   0017-789X . Retrieved 23 March 2019.
  7. 1 2 K. Swift; Pearse, A.-M. (2 February 2006). "Allograft theory: Transmission of devil facial-tumour disease". Nature. 439 (7076): 549. Bibcode:2006Natur.439..549P. doi: 10.1038/439549a . ISSN   1476-4687. PMID   16452970. S2CID   4409863.
  8. Pye, R. J.; Woods, G. M.; Kreiss, A. (13 December 2015). "Devil Facial Tumor Disease". Veterinary Pathology. 53 (4): 726–736. doi:10.1177/0300985815616444. ISSN   1544-2217. PMID   26657222. S2CID   28432058.
  9. 1 2 "Devil scientist wins Japanese prize". ABC News. 1 March 2011. Retrieved 24 June 2019.
  10. Ujvari, Beata; Pearse, Anne-Maree; Peck, Sarah; Harmsen, Collette; Taylor, Robyn; Pyecroft, Stephen; Madsen, Thomas; Papenfuss, Anthony T.; Belov, Katherine (7 January 2013). "Evolution of a contagious cancer: epigenetic variation in Devil Facial Tumour Disease". Proceedings of the Royal Society B: Biological Sciences. 280 (1750): 20121720. doi:10.1098/rspb.2012.1720. PMC   3574417 . PMID   23135679.
  11. "The Australian Museum Eureka Prize Winners for 2011" . theaustralian.com.au. 6 September 2011. Retrieved 23 March 2019.