Protothecosis

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Protothecosis
Prototheca zopfii.jpg
Histologic stain of a Prototheca zopfii infection in a dog
Specialty Infectious diseases   OOjs UI icon edit-ltr-progressive.svg

Protothecosis, otherwise known as Algaemia, is a disease found in dogs, cats, cattle, and humans caused by a type of green alga known as Prototheca that lacks chlorophyll and enters the human or animal bloodstream. It and its close relative Helicosporidium are unusual in that they are actually green algae that have become parasites. [1] The two most common species are Prototheca wickerhamii and Prototheca zopfii . Both are known to cause disease in dogs, while most human cases are caused by P. wickerhami. [2] Prototheca is found worldwide in sewage and soil. Infection is rare despite high exposure, and can be related to a defective immune system. [3] In dogs, females and Collies are most commonly affected. [4]

Contents

The first human case was identified in 1964 in Sierra Leone. [5]

Cause

Photomicrograph of Prototheca wickerhamii infection in a human. Note the floret-like arrangements. Hematoxylin and eosin stain. Prototheca wickerhamii.hematoxylin eosin stain.jpg
Photomicrograph of Prototheca wickerhamii infection in a human. Note the floret-like arrangements. Hematoxylin and eosin stain.
Photomicrograph of Prototheca wickerhamii infection in a human. Note the floret-like arrangements. Gomori methenamine silver(GMS) stain. Prototheca wickerhamii.GMS.jpg
Photomicrograph of Prototheca wickerhamii infection in a human. Note the floret-like arrangements. Gomori methenamine silver(GMS) stain.
Photomicrograph of Prototheca wickerhamii infection in a human. Note the floret-like arrangements. Periodic acid-Schiff(PAS) stain. Prototheca wickerhamii.PAS.jpg
Photomicrograph of Prototheca wickerhamii infection in a human. Note the floret-like arrangements. Periodic acid-Schiff(PAS) stain.

Prototheca has been thought to be a mutant of Chlorella , a type of single-celled green alga. However, while Chlorella contains galactose and galactosamine in the cell wall, Prototheca lacks these. Also, Chlorella obtains its energy through photosynthesis, while Prototheca is saprotrophic, feeding on dead and decaying organic matter. When Prototheca was first isolated from slime flux of trees in 1894, it was thought to be a type of fungus. [6] Its size varies from 2 to 15 micrometres. [7]

Treatment

Treatment with amphotericin B has been reported. [8]

In cattle

Cattle can be affected by protothecal enteritis and mastitis. [9] Protothecal mastitis is endemic worldwide, although most cases of infected herds have been reported in Germany, the United States, and Brazil. [10]

In dogs

Disseminated protothecosis is most commonly seen in dogs. The algae enters the body through the mouth or nose and causes infection in the intestines. From there it can spread to the eye, brain, and kidneys. Symptoms can include diarrhea, weight loss, weakness, inflammation of the eye (uveitis), retinal detachment, ataxia, and seizures. [11]

Dogs with acute blindness and diarrhea that develop exudative retinal detachment should be assessed for protothecosis. [6] Diagnosis is through culture or finding the organism in a biopsy, cerebrospinal fluid, vitreous humour, or urine. Treatment of the disseminated form in dogs is very difficult, although use of antifungal medication has been successful in a few cases. [4] Prognosis for cutaneous protothecosis is guarded and depends on the surgical options. Prognosis for the disseminated form is grave. This may be due to delayed recognition and treatment. [3]

See also

Related Research Articles

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<i>Prototheca wickerhamii</i> Species of alga

Prototheca wickerhamii is a ubiquitous green alga that does not have chlorophyll. It is widely present in the environment but is a rare cause of opportunistic infection in humans (protothecosis).

<i>Staphylococcus capitis</i> Species of bacterium

Staphylococcus capitis is a coagulase-negative species (CoNS) of Staphylococcus. It is part of the normal flora of the skin of the human scalp, face, neck, scrotum, and ears and has been associated with prosthetic valve endocarditis, but is rarely associated with native valve infection.

Algaemia is a secondary term that refers to the emerging condition in which green algae enter the bloodstream. Members of the genus Prototheca are the most common algae that leads to algaemia. Prototheca and Chlorella, which is extremely rare, are the only two known algae genera capable of inflicting disease on mammals, including humans, through invasion of host tissue. The majority of cases are observed in dairy cattle as a cause of bovine mastitis as well as other domesticated animals. Cases of algaemia have been observed in dogs and cats as well. Few cases have been observed in humans. Human cases of algaemia or, protothecosis, are examined on a case-by-case basis due to the particularity of each case. Protothecosis infection is classified based on the symptoms: (i) cutaneous lesions, (ii) olecranon bursitis, and (iii) disseminated or systemic type infections.

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<i>Mycoplasma haemofelis</i> Parasitic bacterium

Mycoplasma haemofelis is a gram-negative epierythrocytic parasitic bacterium. It often appears in bloodsmears as small (0.6μm) coccoid bodies, sometimes forming short chains of three to eight organisms. It is usually the causative agent of feline infectious anemia (FIA) in the United States.

Sagenomella is a genus of filamentous Ascomycota fungus that has reported to cause systemic illness in animals. The genus was circumscribed by Walter Gams in 1978.

Enterobacter taylorae is a Gram-negative bacteria formerly known as Enteric Group 19, and also known as Enterobacter cancerogenus. Strains of E. taylorae are positive for: Voges-Proskauer, citrate utilization, arginine dihydrolase and malonate utilization. They ferment D-glucose and also ferment D-mannitol, L-rhamnose and cellobiose. They are negative for indole production, urea hydrolysis, lysine decarboxylase and fermentation of adonitol, D-sorbitol and raffinose. It occurs in human clinical specimens, being isolated from blood and from spinal fluid. It is known to cause infections and is not susceptible to penicillins nor cephalosporins.

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Prototheca zopfii is an ubiquitous achlorophyllic green alga. It is a known cause of mastitis in cattle.

Chlorellosis is a disease caused by the infection of Chlorella, a type of microalgae containing large amount of chloroplasts. It is mainly found in sheep and cattle, while cases in humans, dogs, antelopes, beavers, camels and fish, were also reported. Symptoms of Chlorellosis including focal cutaneous lesions, lymphadenitis, and peritonitis.

References

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