Interstate 75 (I-75) is a major north–south Interstate Highway in the Great Lakes and Southeastern regions of the United States. As with most Interstates that end in 5, it is a major cross-country, north–south route, traveling from State Road 826 and SR 924 on the Hialeah–Miami Lakes border to Sault Ste. Marie, Michigan, at the Canadian border. It is the second-longest north–south Interstate Highway and the seventh-longest Interstate Highway overall.
Interstate 64 (I-64) is an east–west Interstate Highway in the Eastern United States. Its western terminus is at I-70, U.S. Route 40 (US 40), and US 61 in Wentzville, Missouri. Its eastern terminus is at the Bowers Hill Interchange with I-264 and I-664 at Bower's Hill in Chesapeake, Virginia. I-64 connects Greater St. Louis, the Louisville metropolitan area, the Lexington–Fayette metropolitan area, the Charleston metropolitan area, the Greater Richmond Region, and Hampton Roads.
U.S. Route 27 or U.S. Highway 27 (US 27) is a north–south United States Numbered Highway in the Southern and Midwestern U.S. The southern terminus is at US 1 in Miami, Florida. The northern terminus is at Interstate 69 (I-69) in Fort Wayne, Indiana. From Miami, it goes up the center of Florida, then west to Tallahassee, Florida, and north through such cities and towns as Columbus, Georgia; Rome, Georgia; Chattanooga, Tennessee; Lexington, Kentucky; Cincinnati, Ohio; Oxford, Ohio; Richmond, Indiana; and Fort Wayne, Indiana. It once extended north through Lansing, Michigan, to Cheboygan, Mackinaw City, and, for about three years, even as far as St. Ignace. US 27 was first signed in 1926, replacing what had been the eastern route of the Dixie Highway in many states.
U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from 5 miles (8.0 km) east of Chouteau, Oklahoma, to 8 miles (13 km) west of the Arkansas state line. It runs the entire length of the Oklahoma Panhandle and traverses the Missouri Bootheel.
U.S. Route 60 is a major east–west United States highway, traveling 2,655 miles (4,273 km) from southwestern Arizona to the Atlantic Ocean coast in Virginia. The highway's eastern terminus is in Virginia Beach, Virginia, where it is known as Pacific Avenue, in the city's Oceanfront resort district at the intersection of 5th Street and Winston-Salem Avenue. Its original western terminus was in Springfield, Missouri; it was then extended to Los Angeles, California, but in 1964, it was truncated to end southwest of Brenda, Arizona, at an interchange with Interstate 10 (I-10) after the US 60 highway designation was removed from California. I-10 replaced US 60 from Beaumont, California, to Arizona, and California State Route 60 (SR 60) replaced US 60 from Los Angeles to Beaumont.
U.S. Route 11 or U.S. Highway 11 (US 11) is a major north–south United States Numbered Highway extending 1,645 miles (2,647 km) across the eastern U.S. The southern terminus of the route is at US 90 in Bayou Sauvage National Wildlife Refuge in eastern New Orleans, Louisiana. The northern terminus is at the Rouses Point–Lacolle 223 Border Crossing in Rouses Point, New York. The route continues across the border into Canada as Route 223. US 11, created in 1926, maintains most of its original route. The route north of Knoxville, Tennessee, follows a route similar to Interstate 81 (I-81). While it is signed as a north–south route, it physically travels in a northeast–southwest direction.
U.S. Route 25 or U.S. Highway 25 (US 25) is a north–south United States Numbered Highway that runs for 750 miles (1,210 km) in the Southern and Midwestern U.S. Its southern terminus is in Brunswick, Georgia, from where it proceeds mostly due north, passing through the cities of Augusta, Georgia; Greenville, South Carolina; and Asheville, North Carolina, before dividing into two branches, known as US 25W and US 25E between Newport, Tennessee, and North Corbin, Kentucky. After passing through Richmond and Lexington, Kentucky, it reaches its northern terminus at Ohio state line in Covington, Kentucky. The route is an important crossing of the Appalachian Mountains, and it is covered by three of the corridors of the Appalachian Development Highway System (ADHS). When the highway was originally established in 1926, the route extended from North Augusta, South Carolina, to Port Huron, Michigan. The southern end was extended to its current terminus in 1936, while the northern end was truncated in 1974.
U.S. Route 501 is a spur of U.S. Route 1. It runs 355 miles (571 km) from Buena Vista, Virginia at U.S. Route 60 to Myrtle Beach, South Carolina at U.S. Route 17 Business. It passes through the states of Virginia, North Carolina and South Carolina. From Durham to Laurinburg, a 108-mile (174 km) section of US 501 overlaps U.S. Route 15. Sections of US 15-501 also share routings with U.S. Route 1 in sections near Sanford, North Carolina and Aberdeen, North Carolina.
U.S. Route 460 (US 460) is an auxiliary route of U.S. Route 60. It currently runs for 655 miles (1,054 km) from Norfolk, Virginia, at its parent route U.S. Route 60 at Ocean View to Frankfort, Kentucky, intersecting its parent route once again. It passes through the states of Virginia, West Virginia, and Kentucky. It goes through the cities and towns of Norfolk, Portsmouth, Suffolk, Petersburg, Farmville, Lynchburg, Roanoke, Christiansburg, Blacksburg, Tazewell, and Grundy, in Virginia; Princeton and Bluefield in West Virginia; and Pikeville, Georgetown, and Frankfort in Kentucky.
U.S. Route 127 (US 127) is a 758-mile-long (1,220 km) north–south U.S. Highway in the eastern half of the United States. The southern terminus of the route is at US 27 in Chattanooga, Tennessee. The northern terminus is at Interstate 75 (I-75) near Grayling, Michigan. Since 1987, it has been the core of the annual World's Longest Yard Sale, also known as the Highway 127 Corridor Sale, which now stretches 690 miles (1,110 km) from Addison, Michigan, to Gadsden, Alabama. The sale, held every August, was started to demonstrate that the older U.S. Highway System has something to offer that the Interstate Highway System does not. In Michigan, US 127 tripled in length in 2002, taking mileage from its parent, US 27.
State Route 40 is a primary state highway in the southern part of the U.S. state of Virginia. It runs from SR 8 at Woolwine east to SR 10 at Spring Grove, about half the width of Virginia. It is the longest state-numbered route in Virginia.
U.S. Route 221 (US 221) is a part of the U.S. Highway System that runs from Perry, Florida to Lynchburg, Virginia. In Virginia, the U.S. Highway runs 149.61 miles (240.77 km) from the North Carolina state line near Independence north to its northern terminus at US 29 Business, US 460 Business, and US 501 Business in Lynchburg. US 221 connects Independence, Galax, and Hillsville in Southwest Virginia while running concurrently with US 58. The U.S. Highway connects those communities with Roanoke via Floyd County, within which US 221 is the main east–west highway. Entering Bedford County, US 221 exits the Blue Ridge Mountains; it then passes through the Piedmont town of Bedford on its way to Lynchburg and shares a brief overlap with US 460 Business through the town. The U.S. Highway also runs concurrently with US 460 from Roanoke to Bedford and parallels that U.S. Highway from Bedford to Lynchburg.
U.S. Route 27 (US 27) is a part of the United States Numbered Highway System that runs from Miami, Florida, to Fort Wayne in the U.S. state of Indiana. In Indiana, it is a state road that enters the state in College Corner, Ohio, and West College Corner. The 117.765 miles (189.524 km) of US 27 that lie within Indiana serve as a major conduit. Most of the highway is listed on the National Highway System. Various sections are a rural two-lane highway or an urbanized four-lane divided highway. The northernmost community along the highway is Fort Wayne in the northeast part of the state. The highway ends at an interchange with Interstate 69 (I-69) north of downtown Fort Wayne after serving the east central and northeast regions of Indiana.
Interstate 40 (I-40) is an east–west Interstate Highway that has a 284.69-mile (458.16 km) section in the U.S. state of Arkansas, connecting Oklahoma to Tennessee. The route enters Arkansas from the west just north of the Arkansas River near Dora. It travels eastward across the northern portion of the state, connecting the cities of Fort Smith, Clarksville, Russellville, Morrilton, Conway, North Little Rock, Forrest City, and West Memphis. I-40 continues into Tennessee, heading through Memphis. The highway has major junctions with I-540 at Van Buren, I-49 at Alma, I-30 in North Little Rock, and I-55 to Blytheville.
U.S. Route 25 (US 25) runs for 176.882 miles (284.664 km) across the state of Kentucky from the split between US 25E and US 25W in North Corbin to US 42/US 127 at the Ohio state line in Covington.
U.S. Route 127 (US 127) in Kentucky runs 207.7 miles (334.3 km) from the Tennessee state line in rural Clinton County to the Ohio state line in Cincinnati. The southern portion of the route is mostly rural, winding through various small towns along the way. It later runs through the state capital of Frankfort before continuing north, eventually passing through several Cincinnati suburbs in Northern Kentucky, joining US 42 near Warsaw and US 25 in Florence before crossing the Ohio River via the Clay Wade Bailey Bridge.
Kentucky Route 227 is a 52.762-mile-long (84.912 km) state highway in Kentucky that runs from U.S. Route 460 near Georgetown, Kentucky to US 42 and KY 36 in Carrollton, Kentucky.
Kentucky Route 2354 is a state highway in the city of Owenton in Owen County, Kentucky. The highway runs 0.454 miles (0.731 km) along Roland Avenue from KY 22 north to U.S. Route 127 and KY 227. KY 2354 provides a western bypass of downtown Owenton for traffic between KY 22 and US 127.
Kentucky Route 191 (KY 191) is a 31.1-mile-long (50.1 km) state highway in the U.S. state of Kentucky. The highway connects Campton and West Liberty with mostly rural areas of Wolfe and Morgan counties.
Kentucky Route 627 is a 30.367-mile-long (48.871 km) north–south state highway in east-central Kentucky. It traverses portions of northern Madison, Clark, and southern Bourbon counties.
US 25 / US 421 in Richmond 
I-64 at Winchester 
US 27 / US 68 / US 460 in Paris 
I-75 near Georgetown 
US 127 at Owenton 
I-71 near Carrollton 
US 42 in Carrollton 
