Bromethalin

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Bromethalin
Brometalin Formula V.2.svg
Names
Preferred IUPAC name
N-Methyl-2,4-dinitro-N-(2,4,6-tribromophenyl)-6-(trifluoromethyl)aniline
Other names
2,4,6-Tribromo-N-[2,4-dinitro-6-(trifluoromethyl)phenyl]-N-methylaniline
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.109.042 OOjs UI icon edit-ltr-progressive.svg
KEGG
PubChem CID
UNII
  • InChI=1S/C14H7Br3F3N3O4/c1-21(13-9(16)2-6(15)3-10(13)17)12-8(14(18,19)20)4-7(22(24)25)5-11(12)23(26)27/h2-5H,1H3 Yes check.svgY
    Key: USMZPYXTVKAYST-UHFFFAOYSA-N Yes check.svgY
  • InChI=1/C14H7Br3F3N3O4/c1-21(13-9(16)2-6(15)3-10(13)17)12-8(14(18,19)20)4-7(22(24)25)5-11(12)23(26)27/h2-5H,1H3
    Key: USMZPYXTVKAYST-UHFFFAOYAX
  • Brc2cc(Br)cc(Br)c2N(c1c([N+]([O-])=O)cc([N+]([O-])=O)cc1C(F)(F)F)C
Properties
C14H7Br3F3N3O4
Molar mass 577.93 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Bromethalin is a neurotoxic rodenticide that damages the central nervous system. [1]

Contents

History

Bromethalin was discovered in the early 1980s through an approach to find replacement rodenticides for first-generation anticoagulants, especially to be useful against rodents that had become resistant to Warfarin-type anticoagulant poisons. A structured study was undertaken to develop a substance that would be both poisonous to rodents, but also would be readily eaten by rodents. Bromethalin—N-methyl-2,4-dinitro-N (2,4,6-tribromophenyl)-6-(trifluoromethyl) benzeneamine— was the outcome of that study, as the specific formulation had both desired rodenticidal properties. [1]

Mechanism of action

Bromethalin works by being metabolised to n-desmethyl-bromethalin and uncoupling mitochondrial oxidative phosphorylation, which causes a decrease in adenosine triphosphate (ATP) synthesis. The decreased ATP inhibits the activity of the Na/K ATPase enzyme, thereby leading to a subsequent buildup of cerebral spinal fluid (CSF) and vacuolization of myelin. The excess CSF results in increased intracranial pressure, which in turn permanently damages neuronal axons. This damage to the central nervous system can cause paralysis, convulsions, and death. [1] [2] [ full citation needed ]

Risk of poisoning to humans and pets

Despite risk of severe symptoms and death, most unintentional pediatric exploratory exposures (licking or tasting a pellet) have not shown serious effects, and no deaths have been reported at this time in children, though toxicity is possible if significant amounts are ingested. [3] Due to need for active metabolite generation to produce toxicity, fatal toxicity may be delayed by hours to days. [4] All cases should be managed in consultation with a local poison control center. All intentional ingestions for self harm carry significant risk of death or severe neurologic effects and require monitoring in a hospital setting. [3]

In humans the most common initial effects of unintentional exposure are nausea, vomiting, abdominal pain, and diarrhea, though delayed seizures have been reported. [3] No antidote for bromethalin is known; care is symptomatic and supportive.

In pets, signs to watch for include severe muscle tremors, hyperexcitability, fits, extreme sensitivity to being touched (hyperesthesia) and seizures that appear to be caused by light or noise. [5] Owners of animals that have eaten bromethalin accidentally should seek immediate veterinary attention and be decontaminated. Contacting an animal poison control center can help ensure that timely and appropriate therapy is started.[ citation needed ]

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References

  1. 1 2 3 Dreikorn, Barry A.; O'Doherty, George O. P. (1984). "The Discovery and Development of Bromethalin, an Acute Rodenticide with a Unique Mode of Action". Pesticide Synthesis Through Rational Approaches. ACS Symposium Series. Vol. 255. pp. 45–63. doi:10.1021/bk-1984-0255.ch004. ISBN   0-8412-0852-2.
  2. Bromethalin, Animal Disease Diagnostic Laboratory, Spring 1997 Newsletter
  3. 1 2 3 Feldman, Ryan; Stanton, Matthew; Borys, Douglas; Kostic, Mark; Gummin, David (November 2019). "Medical outcomes of bromethalin rodenticide exposures reported to US poison centers after federal restriction of anticoagulants". Clinical Toxicology. 57 (11): 1109–1114. doi: 10.1080/15563650.2019.1582776 . ISSN   1556-9519. PMID   30892957.
  4. Pasquale-Styles, Melissa A.; Sochaski, Mark A.; Dorman, David C.; Krell, Willane S.; Shah, Aashit K.; Schmidt, Carl J. (September 2006). "Fatal bromethalin poisoning". Journal of Forensic Sciences. 51 (5): 1154–1157. doi:10.1111/j.1556-4029.2006.00218.x. ISSN   0022-1198. PMID   17018099. S2CID   33324699.
  5. Peterson, Michael E. (February 2013). "Bromethalin". Topics in Companion Animal Medicine. 28 (1): 21–23. doi:10.1053/j.tcam.2013.03.005. ISSN   1946-9837. PMID   23796484.