Pasteurella

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Pasteurella
PHIL 3621.tif
Gram-stained photomicrograph depicting numerous Pasteurella multocida bacteria
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Bacteria
Phylum: Pseudomonadota
Class: Gammaproteobacteria
Order: Pasteurellales
Family: Pasteurellaceae
Genus: Pasteurella
Trevisan 1887
Species

P. aerogenes
P. anatis
P. avium
P. bettyae
P. caballi
P. canis
P. dagmatis
P. gallicida
P. gallinarum
P. granulomatis
P. langaaensis
P. lymphangitidis
P. mairii
P. multocida
P. oralis
P. pneumotropica
P. skyensis
P. stomatis
P. testudinis
P. trehalosi
P. ureae
P. volantium

Contents

Pasteurella is a genus of Gram-negative, facultatively anaerobic bacteria. [1] [2] Pasteurella species are nonmotile and pleomorphic, and often exhibit bipolar staining ("safety pin" appearance). Most species are catalase- and oxidase-positive. [3] The genus is named after the French chemist and microbiologist, Louis Pasteur, who first identified the bacteria now known as Pasteurella multocida as the agent of chicken cholera.

Pathogenesis

Many Pasteurella species are zoonotic pathogens, and humans can acquire an infection from domestic animal bites. [4] [5] In cattle, sheep, and birds, Pasteurella species can cause a life-threatening pneumonia; in cats and dogs, however, Pasteurella is not a cause of disease, and constitutes part of the normal flora of the nose and mouth. [6] Pasteurella haemolytica is a species that infects mainly cattle and horses: P. multocida is the most frequent causative agent in human Pasteurella infection. [7] Common symptoms of pasteurellosis in humans include swelling, cellulitis, and bloody drainage at the site of the wound. Infection may progress to nearby joints, where it can cause further swelling, arthritis, and abscesses. [6]

Pasteurella spp. are generally susceptible to chloramphenicol, the penicillins, tetracycline, and the macrolides. [6]

The common occurrence of the bacteria is a reason to be medically proactive and defensive (antibacterial treatments are often necessary) if a bite occurs. [8] Several vaccine preparations were used to prevent Pasteurella infection. [9] New regimens for vaccination and vaccine formulation [10] [11] showed to be promising for the control of the pathogen.

In animals

P. multocida is also known to cause morbidity and mortality in rabbits. The predominant syndrome is upper respiratory disease. P. multocida can be endemic among rabbit colonies and is often transmitted through nasal secretions. P. multocida can survive several days in water or moist areas. [12] Pasturella spp. can be transmitted through the bite of a dog. [13] They have also been reported in red kangaroos [14] and potoroos. [15] Pasteurella Bisgaard taxon 45 was identified in late 2023 as the organism that killed nearly 400 elephants in Zimbabwe and Botswana during the summer of 2020 [16] [17]

Antibiotic sensitivity

P. multocida is highly sensitive to enrofloxacin, oxytetracycline, chloramphenicol, and ampicillin. [18]

Possible complications

Osteomyelitis is a possible complication of P. multocida, which can subsequently lead to necrotizing fasciitis. [19]

Related Research Articles

<i>Yersinia pestis</i> Species of bacteria, cause of plague

Yersinia pestis is a gram-negative, non-motile, coccobacillus bacterium without spores that is related to both Yersinia enterocolitica and Yersinia pseudotuberculosis, the pathogen from which Y. pestis evolved and responsible for the Far East scarlet-like fever. It is a facultative anaerobic organism that can infect humans via the Oriental rat flea. It causes the disease plague, which caused the Plague of Justinian and the Black Death, the deadliest pandemic in recorded history. Plague takes three main forms: pneumonic, septicemic, and bubonic. Yersinia pestis is a parasite of its host, the rat flea, which is also a parasite of rats, hence Y. pestis is a hyperparasite.

<span class="mw-page-title-main">Tularemia</span> Infectious disease caused by the bacterium Francisella tularensis

Tularemia, also known as rabbit fever, is an infectious disease caused by the bacterium Francisella tularensis. Symptoms may include fever, skin ulcers, and enlarged lymph nodes. Occasionally, a form that results in pneumonia or a throat infection may occur.

<span class="mw-page-title-main">Pasteurellosis</span> Medical condition

Pasteurellosis is an infection with a species of the bacterial genus Pasteurella, which is found in humans and other animals.

<span class="mw-page-title-main">Septicemic plague</span> Human disease caused by Yersinia pestis

Septicemic plague is one of the three forms of plague, and is caused by Yersinia pestis, a gram-negative species of bacterium. Septicemic plague is a systemic disease involving infection of the blood and is most commonly spread by bites from infected fleas. Septicemic plague can cause disseminated intravascular coagulation and is always fatal when untreated. The other varieties of the plague are bubonic plague and pneumonic plague.

<i>Acinetobacter</i> Genus of bacteria

Acinetobacter is a genus of Gram-negative bacteria belonging to the wider class of Gammaproteobacteria. Acinetobacter species are oxidase-negative, exhibit twitching motility, and occur in pairs under magnification.

<i>Bordetella bronchiseptica</i> Species of bacterium

Bordetella bronchiseptica is a small, gram-negative, rod-shaped bacterium of the genus Bordetella. It can cause infectious bronchitis in dogs and other animals, but rarely infects humans. Closely related to B. pertussis—the obligate human pathogen that causes pertussis ; B. bronchiseptica can persist in the environment for extended periods.

<i>Klebsiella</i> Genus of gram-negative bacteria

Klebsiella is a genus of Gram-negative, oxidase-negative, rod-shaped bacteria with a prominent polysaccharide-based capsule.

<i>Francisella</i> Genus of bacteria

Francisella is a genus of Gram-negative bacteria. They are small coccobacillary or rod-shaped, nonmotile organisms, which are also facultative intracellular parasites of macrophages. Strict aerobes, Francisella colonies bear a morphological resemblance to those of the genus Brucella. Some Francisella species are pathogenic bacteria but some others are endosymbionts of ticks. Ticks do not use any other food source than vertebrate blood and therefore ingest high levels of protein, iron and salt, but few vitamins. To overcome these nutritional deficiencies, ticks have evolved obligate interactions with nutritional endosymbionts, including Francisella endosymbionts. Their experimental elimination typically results in decreased tick survival, molting, fecundity and egg viability, as well as in physical abnormalities, which all are fully restored with an oral supplement of B vitamins. The genome sequencing of Francisella endosymbionts confirmed that they consistently produce three B vitamin types, biotin (vitamin B7), riboflavin (B2) and folate (B9). Francisella endosymbionts are often misidentified as Francisella tularensis; however, Francisella endosymbionts lack virulence genes and cannot infect humans.

<i>Francisella tularensis</i> Species of bacterium

Francisella tularensis is a pathogenic species of Gram-negative coccobacillus, an aerobic bacterium. It is nonspore-forming, nonmotile, and the causative agent of tularemia, the pneumonic form of which is often lethal without treatment. It is a fastidious, facultative intracellular bacterium, which requires cysteine for growth. Due to its low infectious dose, ease of spread by aerosol, and high virulence, F. tularensis is classified as a Tier 1 Select Agent by the U.S. government, along with other potential agents of bioterrorism such as Yersinia pestis, Bacillus anthracis, and Ebola virus. When found in nature, Francisella tularensis can survive for several weeks at low temperatures in animal carcasses, soil, and water. In the laboratory, F. tularensis appears as small rods, and is grown best at 35–37 °C.

<i>Yersinia enterocolitica</i> Species of bacterium

Yersinia enterocolitica is a Gram-negative, rod-shaped bacterium, belonging to the family Yersiniaceae. It is motile at temperatures of 22–29°C (72–84°F), but becomes nonmotile at normal human body temperature. Y. enterocolitica infection causes the disease yersiniosis, which is an animal-borne disease occurring in humans, as well as in a wide array of animals such as cattle, deer, pigs, and birds. Many of these animals recover from the disease and become carriers; these are potential sources of contagion despite showing no signs of disease. The bacterium infects the host by sticking to its cells using trimeric autotransporter adhesins.

Yersiniosis is an infectious disease caused by a bacterium of the genus Yersinia. In the United States, most yersiniosis infections among humans are caused by Yersinia enterocolitica.

<i>Pasteurella multocida</i> Species of bacterium

Pasteurella multocida is a Gram-negative, nonmotile, penicillin-sensitive coccobacillus of the family Pasteurellaceae. Strains of the species are currently classified into five serogroups based on capsular composition and 16 somatic serovars (1–16). P. multocida is the cause of a range of diseases in mammals and birds, including fowl cholera in poultry, atrophic rhinitis in pigs, and bovine hemorrhagic septicemia in cattle and buffalo. It can also cause a zoonotic infection in humans, which typically is a result of bites or scratches from domestic pets. Many mammals and birds harbor it as part of their normal respiratory microbiota.

<span class="mw-page-title-main">Pathogenic bacteria</span> Disease-causing bacteria

Pathogenic bacteria are bacteria that can cause disease. This article focuses on the bacteria that are pathogenic to humans. Most species of bacteria are harmless and are often beneficial but others can cause infectious diseases. The number of these pathogenic species in humans is estimated to be fewer than a hundred. By contrast, several thousand species are part of the gut flora present in the digestive tract.

<span class="mw-page-title-main">Fowl cholera</span> Bacterial disease of birds

Fowl cholera is also called avian cholera, avian pasteurellosis and avian hemorrhagic septicemia.

Haemorrhagic septicaemia (HS) is one of the most economically important pasteurelloses. Haemorrhagic septicaemia in cattle and buffaloes was previously known to be associated with one of two serotypes of P. multocida: Asian B:2 and African E:2 according to the Carter-Heddleston system, or 6:B and 6:E using the Namioka-Carter system.

Pasteurella canis is a Gram-negative, nonmotile, penicillin-sensitive coccobacillus of the family Pasteurellaceae. Bacteria from this family cause zoonotic infections in humans, which manifest themselves as skin or soft-tissue infections after an animal bite. It has been known to cause serious disease in immunocompromised patients.

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<span class="mw-page-title-main">Jessie Isabelle Price</span> Veterinary microbiologist

Jessie Isabelle Price was a veterinary microbiologist. She isolated and reproduced the cause of the most common life-threatening disease in duck farming in the 1950s and developed vaccines for this and other avian diseases. A graduate of Cornell University, where she gained a PhD (1959), she worked first at the Cornell Duck Research Laboratory and later at the USGS National Wildlife Health Center. She served as chair of the Predoctoral Minority Fellowship Ad Hoc Review Committee of the American Society for Microbiology (ASM), and as president of Graduate Women in Science.

<span class="mw-page-title-main">Cat bite</span> Medical condition

Cat bites are bites inflicted upon humans, other cats, and other animals by the domestic cat. Data from the United States show that cat bites represent between 5–15% of all animal bites inflicted to humans, but it has been argued that this figure could be the consequence of under-reporting as bites made by Felis catus are considered by some to be unimportant. Though uncommon, cat bites can sometimes cause Rabies lead to complications and, very rarely, death.

References

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