UGT1A10

UGT1A10
Identifiers
Aliases	UGT1A10 , UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J, UDP glucuronosyltransferase family 1 member A10, UGT1-01, UGT-1A, hUG-BR1, UGT1, UGT1A, UGT1.1, GNT1, UGT1A1
External IDs	OMIM: 606435 MGI: 3576092 HomoloGene: 133281 GeneCards: UGT1A10
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.1 Start 233,636,448 bp [1] End 233,773,300 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 D Start 87,998,522 bp [2] End 88,146,719 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum rectum gallbladder appendix gastric mucosa body of stomach islet of Langerhans urinary bladder fundus smooth muscle tissue Top expressed in hepatobiliary system liver duodenum colon renal cortex proximal tubule stomach kidney ileum jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity retinoic acid binding hexosyltransferase activity protein homodimerization activity glycosyltransferase activity protein heterodimerization activity enzyme binding protein kinase C binding glucuronosyltransferase activity UDP-glycosyltransferase activity Cellular component integral component of membrane membrane intracellular membrane-bounded organelle endoplasmic reticulum endoplasmic reticulum membrane Biological process negative regulation of cellular glucuronidation xenobiotic glucuronidation flavone metabolic process metabolism negative regulation of glucuronosyltransferase activity negative regulation of fatty acid metabolic process cellular glucuronidation flavonoid glucuronidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54575 394434 Ensembl ENSG00000242515 ENSMUSG00000090175 UniProt Q9HAW8 Q62452 RefSeq (mRNA) NM_019075 NM_201644 RefSeq (protein) NP_061948 NP_964006 Location (UCSC) Chr 2: 233.64 – 233.77 Mb Chr 1: 88 – 88.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

UDP-glucuronosyltransferase 1-10 is an enzyme that in humans is encoded by the UGT1A10 gene. ^{[5] [6] [7]}

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. ^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Irinotecan Pathway edit]]

Irinotecan Pathway edit

1. The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359".

References

1. GRCh38: Ensembl release 89: ENSG00000242515 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000090175 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (Oct 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID   9295054.
6. Mojarrabi B, Mackenzie PI (Oct 1997). "The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid". Biochem Biophys Res Commun. 238 (3): 775–8. doi:10.1006/bbrc.1997.7388. PMID   9325166.
7. "Entrez Gene: UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10".

Further reading

• Tukey RH, Strassburg CP (2000). "Human UDP-glucuronosyltransferases: metabolism, expression, and disease". Annu. Rev. Pharmacol. Toxicol. 40: 581–616. doi:10.1146/annurev.pharmtox.40.1.581. PMID   10836148.
• Tukey RH, Strassburg CP (2001). "Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract". Mol. Pharmacol. 59 (3): 405–14. doi:10.1124/mol.59.3.405. PMID   11179432. S2CID   21500183.
• King CD, Rios GR, Green MD, Tephly TR (2001). "UDP-glucuronosyltransferases". Curr. Drug Metab. 1 (2): 143–61. doi:10.2174/1389200003339171. PMID   11465080.
• Harding D, Jeremiah SJ, Povey S, Burchell B (1990). "Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1". Ann. Hum. Genet. 54 (Pt 1): 17–21. doi:10.1111/j.1469-1809.1990.tb00356.x. PMID   2108603. S2CID   35661967.
• van Es HH, Bout A, Liu J, et al. (1993). "Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37". Cytogenet. Cell Genet. 63 (2): 114–6. doi:10.1159/000133513. PMID   8467709.
• Strassburg CP, Oldhafer K, Manns MP, Tukey RH (1997). "Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue". Mol. Pharmacol. 52 (2): 212–20. doi:10.1124/mol.52.2.212. PMID   9271343. S2CID   37098463.
• Mojarrabi B, Mackenzie PI (1998). "Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon". Biochem. Biophys. Res. Commun. 247 (3): 704–9. doi:10.1006/bbrc.1998.8843. PMID   9647757.
• Strassburg CP, Strassburg A, Nguyen N, et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus". Biochem. J. 338 (2): 489–98. doi:10.1042/0264-6021:3380489. PMC   1220077 . PMID   10024527.
• Cheng Z, Radominska-Pandya A, Tephly TR (1999). "Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10". Drug Metab. Dispos. 27 (10): 1165–70. PMID   10497143.
• Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine". J. Biol. Chem. 275 (46): 36164–71. doi: 10.1074/jbc.M002180200 . PMID   10748067.
• Gong QH, Cho JW, Huang T, et al. (2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus". Pharmacogenetics. 11 (4): 357–68. doi:10.1097/00008571-200106000-00011. PMID   11434514.
• Zheng Z, Fang JL, Lazarus P (2002). "Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues". Drug Metab. Dispos. 30 (4): 397–403. doi:10.1124/dmd.30.4.397. PMID   11901093.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jinno H, Saeki M, Tanaka-Kagawa T, et al. (2003). "Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10". Drug Metab. Dispos. 31 (5): 528–32. doi:10.1124/dmd.31.5.528. PMID   12695339.