CENPM

CENPM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4P0T, 4WAU
Identifiers
Aliases	CENPM , C22orf18, CENP-M, PANE1, bK250D10.2, centromere protein M
External IDs	OMIM: 610152 MGI: 1913820 HomoloGene: 11438 GeneCards: CENPM
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.2 Start 41,938,737 bp [1] End 41,947,152 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 82,117,980 bp [2] End 82,128,949 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube ganglionic eminence bronchial epithelial cell bone marrow appendix bone marrow cells lymph node stromal cell of endometrium amniotic fluid spleen Top expressed in morula secondary oocyte medial ganglionic eminence yolk sac internal carotid artery blastocyst neural tube external carotid artery thymus maxillary prominence More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 79019 66570 Ensembl ENSG00000100162 ENSMUSG00000068101 UniProt Q9NSP4 Q9CQA0 RefSeq (mRNA) NM_001002876 NM_001110215 NM_001304370 NM_001304371 NM_001304372 NM_001304373 NM_024053 NM_001080158 NM_025639 NM_178269 RefSeq (protein) NP_001002876 NP_001103685 NP_001291299 NP_001291300 NP_001291301 NP_001291302 NP_076958 NP_001073627 NP_079915 NP_840000 Location (UCSC) Chr 22: 41.94 – 41.95 Mb Chr 15: 82.12 – 82.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene. ^{[5] [6] [7]}

An alternative transcript of the CENPM gene encodes a leukocyte antigen that is selectively expressed in B-lymphoid cells. ^{[8] [9]} Centromere protein M is involved in centromere assembly and immune response. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000100162 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068101 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID   16622420. S2CID   26974412.
6. Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi:10.1038/ncb1397. PMID   16622419. S2CID   205286556.
7. "Entrez Gene: CENPM centromere protein M".
8. Brickner AG, Evans AM, Mito JK, Xuereb SM, Feng X, Nishida T, Fairfull L, Ferrell RE, Foon KA, Hunt DF, Shabanowitz J, Engelhard VH, Riddell SR, Warren EH (2006). "The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL". Blood. 107 (9): 3779–86. doi:10.1182/blood-2005-08-3501. PMC   1895781 . PMID   16391015.
9. Bierie B, Edwin M, Melenhorst JJ, Hennighausen L (July 2004). "The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells". Gene Expression Patterns. 4 (4): 389–95. doi:10.1016/j.modgep.2004.01.008. PMID   15183305.
10. Huang H, Deng H, Yang Y, Tang Z, Yang S, Mu Y, Cui W, Yuan J, Wu Z, Li K (2010). "Molecular characterization and association analysis of porcine PANE1 gene". Molecular Biology Reports. 37 (5): 2571–7. doi:10.1007/s11033-009-9775-0. PMID   19711193. S2CID   20345149.

Further reading

• Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID   15009096. S2CID   21813024.
• Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (June 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–84. doi: 10.1111/j.1365-2443.2006.00969.x . PMID   16716197.

External links

• Human CENPM genome location and CENPM gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : Q9NSP4 (Human Centromere protein M (CENPM)) at the PDBe-KB .