MOBKL1A

MOB1B
Identifiers
Aliases	MOB1B , MATS2, MOB4A, MOBKL1A, MOB kinase activator 1B
External IDs	OMIM: 609282 MGI: 1915723 HomoloGene: 61676 GeneCards: MOB1B
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q13.3 Start 70,902,326 bp [1] End 71,022,449 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 E1 Start 88,868,714 bp [2] End 88,912,079 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla thymus superior surface of tongue saphenous vein spongy bone medulla oblongata trigeminal ganglion superior vestibular nucleus body of tongue pericardium Top expressed in superior surface of tongue gallbladder seminal vesicula left lobe of liver aortic valve ascending aorta ciliary body atrioventricular valve epithelium of stomach lacrimal gland More reference expression data BioGPS n/a
Gene ontology Molecular function kinase binding protein binding kinase activator activity metal ion binding Cellular component cytoplasm extracellular exosome nucleus nucleolus cytosol Biological process regulation of protein autophosphorylation hippo signaling positive regulation of phosphorylation positive regulation of kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 92597 68473 Ensembl ENSG00000173542 ENSMUSG00000006262 UniProt Q7L9L4 Q8BPB0 RefSeq (mRNA) NM_001244766 NM_001244767 NM_173468 NM_026735 RefSeq (protein) NP_001231695 NP_001231696 NP_775739 NP_081011 Location (UCSC) Chr 4: 70.9 – 71.02 Mb Chr 5: 88.87 – 88.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mps one binder kinase activator-like 1A, also known as Mob1 homolog 1A, is a protein that in humans is encoded by the MOBKL1A gene. ^{[5] [6]}

Function

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. ^[5]

See also

• Hippo signaling pathway

References

1. GRCh38: Ensembl release 89: ENSG00000173542 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006262 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MOB1".
6. Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (June 2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi: 10.1074/jbc.M401999200 . PMID   15067004.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (2004). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". J. Biol. Chem. 279 (34): 35228–35. doi: 10.1074/jbc.M404542200 . PMID   15197186.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Chow A, Hao Y, Yang X (2010). "Molecular characterization of human homologs of yeast MOB1". Int. J. Cancer. 126 (9): 2079–89. doi: 10.1002/ijc.24878 . hdl: 1974/1468 . PMID   19739119. S2CID   33688672.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.