U.S. Route 74 (US 74) is an east–west United States highway that runs for 515 miles (829 km) from Chattanooga, Tennessee to Wrightsville Beach, North Carolina. Primarily in North Carolina, it serves as an important highway from the mountains to the sea, connecting the cities of Asheville, Charlotte and Wilmington. It is known as Andrew Jackson Highway throughout most of North Carolina.
U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with both serving as southern termini. It reaches its northernmost point at Elizabethton, Tennessee, just northeast of Johnson City. Because of its unusual "north–south–north" routing, U.S. Route 321 intersects both Interstate 40 and U.S. Route 70 three separate times. The highway serves different roles in each state: An alternate route to interstates in South Carolina, a major highway in North Carolina, and a scenic route in Tennessee.
U.S. Route 158 (US 158) is an east–west United States highway that runs for 350 miles (560 km) from Mocksville to Whalebone Junction in Nags Head, entirely in the state of North Carolina. It is also a critical route that connects the cities of Winston-Salem, Summerfield, and Reidsville with one another.
U.S. Route 264 (US 264) is an east–west United States Highway located completely within the U.S. state of North Carolina, running for 215.7 miles (347.1 km). Its western terminus is located at Interstate 87 (I-87), I-440, and US 64 in Raleigh. US 264 is a freeway between Raleigh and Wilson, with segments running concurrently with I-87, I-587, I-795, and US 64. The highway is largely parallel to I-587 between Wilson and Greenville and primarily serves smaller communities such as Saratoga and Farmville. East of Greenville, US 264 is an important highway connecting communities such as Washington, Belhaven, Swan Quarter, and Engelhard. The eastern terminus of US 264 is located at US 64 in Manns Harbor.
North Carolina Highway 75 (NC 75) is a primary state highway in the U.S. state of North Carolina. Its entire length runs through Union County and serves as the primary connector between the towns of Waxhaw, Mineral Springs, and Monroe. The route roughly parallels a CSX railroad line for its entire span.
U.S. Route 64 (US 64) is the longest numbered route in the U.S. state of North Carolina, running 604 miles (972 km) from the Tennessee state line to the Outer Banks. The route passes through the westernmost municipality in the state, Murphy, and one of the most easternmost municipalities, Manteo, making US 64 a symbolic representation of the phrase "from Murphy to Manteo" which is used to refer to the expanse of the state. The highway is a major east–west route through the central and eastern portion of the state.
North Carolina Highway 16 (NC 16) is a 143.8-mile primary state highway in the U.S. state of North Carolina. Traveling in a north–south direction, it connects the cities and towns of Charlotte, Newton, Conover, Taylorsville, Wilkesboro and Jefferson, linking the Charlotte metropolitan area with the mountainous High Country. NC 16 is part of a three-state route 16 that connects the Charlotte region with northwestern West Virginia.
North Carolina Highway 11 is a primary state highway in the U.S. state of North Carolina. Traveling 193.2 miles (310.9 km) in a north–south alignment through Eastern North Carolina, it connects the towns and cities of Wallace, Kenansville, Kinston, Greenville and Murfreesboro.
North Carolina Highway 18 (NC 18) is a primary state highway in the U.S. state of North Carolina. Traveling north–south through the Foothills region, it connects the cities of Shelby, Morganton, Lenoir, Wilkesboro and North Wilkesboro.
North Carolina Highway 87 (NC 87) is a primary state highway in the U.S. state of North Carolina. NC 87 begins in the Atlantic coastal town of Southport and crosses into Virginia at the Virginia state line five miles (8 km) north of Eden in Rockingham County. At 240 miles (390 km) in length, NC 87 is the second longest state highway in the U.S. state of North Carolina with only North Carolina Highway 24 being longer. Labeled as a north–south route, NC 87 travels along a relatively straight southeast–northwest path, connecting Cape Fear region with the Piedmont. It is also the main north-south route connecting the cities of Fayetteville, Sanford, Burlington and Reidsville.
North Carolina Highway 109 (NC 109) is a north–south state highway in North Carolina. It primarily connects small towns in the central Piedmont region of the state. The 117-mile (188 km) route is a two-lane road for most of its length, but the segment between Winston-Salem and Thomasville is being upgraded to a divided 4-lane highway, as it is a major route between the two cities. The central segment of NC 109 passes through the Uwharrie Mountains and the Uwharrie National Forest.
North Carolina Highway 268 (NC 268) is a primary state highway in the U.S. state of North Carolina. It connects many communities as it traverses through the northwestern North Carolina mountains and foothills.
A total of at least 31 special routes of U.S. Route 17 (US 17) exist: 3 in Florida, 5 in South Carolina, 17 in North Carolina, and 6 in Virginia.
U.S. Highway 25 (US 25) is a north–south United States Numbered Highway that runs for 75.4 miles (121.3 km) from the South Carolina state line, near Tuxedo, to the Tennessee state line, near Hot Springs. It is part of the longer US 25, which runs from Brunswick, Georgia, to Covington, Ohio. It is a major north–south route through Western North Carolina.
In the U.S. state of North Carolina U.S. Route 221 (US 221) is a north–south highway that travels through Western North Carolina. From Chesnee, South Carolina to Independence, Virginia, it connects the cities of Rutherfordton, Marion, Boone and Jefferson between the two out-of-state destinations. Its most memorable section, known as the Little Parkway Scenic Byway between Linville and Blowing Rock, offers area visitors a curvier alternative to the Blue Ridge Parkway and access to Grandfather Mountain.
Several special routes of U.S. Route 70 exist. In order from west to east, these special routes are as follows.
North Carolina Highway 81 (NC 81) is a primary state highway in the U.S. state of North Carolina. That runs entirely in Asheville and Buncombe County from US 25 to US 70.
Several special routes of U.S. Route 64 exist. In order from west to east they are as follows.
Several special routes of U.S. Route 29 (US 29) exist. In order from south to north, they are as follows.
Several special routes of U.S. Route 421 exist. In order from south to north they are as follows.
